| Iodine 123-metaiodobenzylguanidine imaging reflect generalized sympathetic activation in patients with left ventricular dysfunction. | |
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MedLine Citation:
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PMID: 15659078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Iodine 123-metaiodobenzylguanidine (MIBG) imaging has been used to assess cardiac sympathetic nerve abnormalities. To determine the role of MIBG imaging as a measure of generalized sympathetic nerve activity, MIBG imaging was evaluated with muscle sympathetic nerve activity (MSNA) and plasma norepinephrine (noradrenaline) level in patients with old myocardial infarction. METHODS: Myocardial MIBG scintigraphy, MSNA and plasma norepinephrine measurement were performed within 3 days in 35 patients with old myocardial infarction. Patients were divided into three groups according to their ejection fraction (EF); preserved (EF > or = 50%, 12 patients), intermediate (35% < EF < 50%, 13 patients), or depressed (EF < or = 35%, 10 patients). The heart to mediastinum (H/M) ratio was obtained 4 h after tracer injection from the chest anterior view image. MIBG washout rate was calculated from the early and delayed images. MSNA was recorded by microneurography. RESULTS: Plasma norepinephrine level had weak negative correlations with early H/M ratio (r = 0.37, P<0.05) and delayed H/M ratio (r = 0.33, P<0.05), and a positive correlation with MIBG washout rate (r = 0.54, P<0.01). MSNA had weak negative correlations with early H/M ratio (r = 0.51, P<0.05) and delayed H/M ratio (r = 0.52, P<0.05). However, a strong correlation was found between MSNA and MIBG washout rate (r = 0.88, P<0.001). Despite no significant differences in plasma norepinephrine level and H/M ratio, patients with intermediate and depressed EF had higher MIBG washout rate and MSNA compared with those with preserved EF. CONCLUSIONS: Increased in cardiac sympathetic nerve activity was associated with augmented sympathetic outflow of the skeletal muscle and hence, MIBG washout rate allow the assessment of general sympathetic nerve activity. |
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Authors:
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Reisuke Yuyama; Fumio Yuasa; Makoto Hikosaka; Jun Mimura; Akihiro Kawamura; Kengo Hatada; Masayuki Motohiro; Masayoshi Iwasaki; Tetsuro Sugiura; Toshiji Iwasaka |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 25 ISSN: 1475-0961 ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-20 Completed Date: 2005-07-20 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 34-9 Citation Subset: IM |
Affiliation:
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The Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan. yuyamar@takii.kmu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine
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administration & dosage*,
pharmacokinetics Electrocardiography / methods Female Heart / innervation, radionuclide imaging Hemodynamics / physiology Humans Male Middle Aged Norepinephrine / blood Radiopharmaceuticals / administration & dosage*, pharmacokinetics Severity of Illness Index Sympathetic Nervous System / physiology*, radionuclide imaging* Time Factors Tomography, Emission-Computed / methods Ventricular Dysfunction, Left / radionuclide imaging*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 51-41-2/Norepinephrine; 77679-27-7/3-Iodobenzylguanidine |
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