Document Detail


Iodine 123-metaiodobenzylguanidine imaging reflect generalized sympathetic activation in patients with left ventricular dysfunction.
MedLine Citation:
PMID:  15659078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Iodine 123-metaiodobenzylguanidine (MIBG) imaging has been used to assess cardiac sympathetic nerve abnormalities. To determine the role of MIBG imaging as a measure of generalized sympathetic nerve activity, MIBG imaging was evaluated with muscle sympathetic nerve activity (MSNA) and plasma norepinephrine (noradrenaline) level in patients with old myocardial infarction. METHODS: Myocardial MIBG scintigraphy, MSNA and plasma norepinephrine measurement were performed within 3 days in 35 patients with old myocardial infarction. Patients were divided into three groups according to their ejection fraction (EF); preserved (EF > or = 50%, 12 patients), intermediate (35% < EF < 50%, 13 patients), or depressed (EF < or = 35%, 10 patients). The heart to mediastinum (H/M) ratio was obtained 4 h after tracer injection from the chest anterior view image. MIBG washout rate was calculated from the early and delayed images. MSNA was recorded by microneurography. RESULTS: Plasma norepinephrine level had weak negative correlations with early H/M ratio (r = 0.37, P<0.05) and delayed H/M ratio (r = 0.33, P<0.05), and a positive correlation with MIBG washout rate (r = 0.54, P<0.01). MSNA had weak negative correlations with early H/M ratio (r = 0.51, P<0.05) and delayed H/M ratio (r = 0.52, P<0.05). However, a strong correlation was found between MSNA and MIBG washout rate (r = 0.88, P<0.001). Despite no significant differences in plasma norepinephrine level and H/M ratio, patients with intermediate and depressed EF had higher MIBG washout rate and MSNA compared with those with preserved EF. CONCLUSIONS: Increased in cardiac sympathetic nerve activity was associated with augmented sympathetic outflow of the skeletal muscle and hence, MIBG washout rate allow the assessment of general sympathetic nerve activity.
Authors:
Reisuke Yuyama; Fumio Yuasa; Makoto Hikosaka; Jun Mimura; Akihiro Kawamura; Kengo Hatada; Masayuki Motohiro; Masayoshi Iwasaki; Tetsuro Sugiura; Toshiji Iwasaka
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  25     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-20     Completed Date:  2005-07-20     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  34-9     Citation Subset:  IM    
Affiliation:
The Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan. yuyamar@takii.kmu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
3-Iodobenzylguanidine / administration & dosage*,  pharmacokinetics
Electrocardiography / methods
Female
Heart / innervation,  radionuclide imaging
Hemodynamics / physiology
Humans
Male
Middle Aged
Norepinephrine / blood
Radiopharmaceuticals / administration & dosage*,  pharmacokinetics
Severity of Illness Index
Sympathetic Nervous System / physiology*,  radionuclide imaging*
Time Factors
Tomography, Emission-Computed / methods
Ventricular Dysfunction, Left / radionuclide imaging*,  ultrasonography
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 51-41-2/Norepinephrine; 77679-27-7/3-Iodobenzylguanidine

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