| Iodine-123-metaiodobenzylguanidine imaging can predict future cardiac events in heart failure patients with preserved ejection fraction. | |
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MedLine Citation:
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PMID: 20824398 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Iodine-123-metaiodobenzylguanidine ((123)I-MIBG) has been used to assess the function of the cardiac sympathetic nervous system in patients with chronic heart failure (HF). The usefulness of (123)I-MIBG imaging for evaluating patients with heart failure with preserved ejection fraction (HFPEF) has not been established. METHODS: We performed (123)I-MIBG scintigraphy and echocardiography and measured the plasma brain natriuretic peptide (BNP) levels of 117 consecutive HF patients (64 men, mean age 66 ± 14 years) with a left ventricular ejection fraction (LVEF) of ≥50% who were admitted to our hospital. Patients were divided into 2 groups according to the New York Heart Association (NYHA) functional class. RESULTS: The (123)I-MIBG delayed heart-to-mediastinum (H/M) ratio was significantly lower, and the washout rate (WR) was higher in patients with HFPEF with advanced NYHA functional class (NYHA functional class I and II vs. III: 1.90 ± 0.34 vs. 1.49 ± 0.32, p < 0.0001; 25.9 ± 13.4 vs. 46.9 ± 16.3%, p < 0.0001, respectively). On the other hand, the (123)I-MIBG WR was not correlated with LVEF and had a weak correlation with plasma BNP levels (R = 0.207, p = 0.0346). Moreover, patients with a high (123)I-MIBG WR showed a poor clinical outcome (p = 0.0033). CONCLUSIONS: (123)I-MIBG imaging provides independent prognostic information in patients with HFPEF. |
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Authors:
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Shigehiko Katoh; Tetsuro Shishido; Daisuke Kutsuzawa; Takanori Arimoto; Shunsuke Netsu; Akira Funayama; Mitsunori Ishino; Takeshi Niizeki; Satoshi Nishiyama; Hiroki Takahashi; Takehiko Miyashita; Takuya Miyamoto; Joji Nitobe; Tetsu Watanabe; Isao Kubota |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-08 |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 24 ISSN: 1864-6433 ISO Abbreviation: Ann Nucl Med Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 679-86 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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