Document Detail

Iodine-123 meta-iodobenzylguanidine scintigraphy: a noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  3170968     Owner:  NLM     Status:  MEDLINE    
Iodine-123 (I-123) meta-iodobenzylguanidine (MIBG) imaging was performed in 31 patients. Three patients were without cardiac disease and 28 had idiopathic dilated cardiomyopathy with various degrees of left ventricular dysfunction. The qualitatively assessed myocardial I-123 MIBG scintigrams and the myocardial versus mediastinal I-123 MIBG uptake ratio were related to I-123 MIBG activity and norepinephrine concentration determined from endomyocardial biopsy samples taken from the right side of the interventricular septum. Scintigrams and the MIBG uptake ratio were also related to plasma catecholamine concentrations, left ventricular ejection fraction and New York Heart Association functional class. Patients with distinct myocardial I-123 MIBG uptake (score 1) had a normal ejection fraction (58 +/- 16%). Patients with diffusely reduced uptake or scintigraphic defects (score 2) had a significantly lower ejection fraction (38 +/- 9%, p less than 0.05), whereas patients with shadowy or no visible myocardial uptake (score 3) had the lowest ejection fraction (23 +/- 6%, p less than 0.002 versus patients with score 2). The scintigraphically determined I-123 MIBG activity in the septal region correlated significantly with I-123 MIBG activity from the endomyocardial biopsy samples (r = 0.78, p less than 0.001, n = 9). The myocardial versus mediastinal I-123 MIBG activity ratio was significantly related to myocardial norepinephrine concentration (r = 0.63, n = 28) and to left ventricular ejection fraction (r = 0.74, n = 31). These data suggest that myocardial I-123 MIBG scintigraphy is a useful noninvasive method for the assessment of myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy.
J Schofer; R Spielmann; A Schuchert; K Weber; M Schlüter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  12     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-11-23     Completed Date:  1988-11-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1252-8     Citation Subset:  AIM; IM    
Department of Cardiology, University Hospital Eppendorf, Hamburg, West Germany.
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MeSH Terms
Cardiomyopathy, Dilated / metabolism,  physiopathology,  radionuclide imaging*
Catecholamines / blood,  metabolism
Heart Conduction System / radionuclide imaging*
Iodine Radioisotopes / diagnostic use
Iodobenzenes / diagnostic use*
Middle Aged
Myocardium / metabolism
Stroke Volume
Sympathetic Nervous System / radionuclide imaging*
Reg. No./Substance:
0/Catecholamines; 0/Iodine Radioisotopes; 0/Iodobenzenes; 77679-27-7/3-Iodobenzylguanidine

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