| Iodine-123-BMIPP myocardial washout and cardiac work during exercise in normal and ischemic hearts. | |
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MedLine Citation:
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PMID: 9098201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iodine-123-BMIPP washout at rest and after exercise was investigated in relation to cardiac work in normal and ischemic myocardium. METHODS: Sixteen healthy volunteers and 10 patients with ischemic heart disease were examined. After injection of 111 MBq of 123I-BMIPP, successive SPECT imaging was performed to evaluate washout ratio (WR) at rest and after mild and maximal exercise. RESULTS: In the healthy volunteers, the mean WR was 3.3 +/- 3.5% after 1 hr of rest and increased during both mild and maximal exercise. The WR showed a better correlation with net pressure rate product (PRP) than with the peak PRP. After maximal exercise, the WR showed a distinct correlation with the net PRP in the range from 200-300 x 10(3) mmHg/min and then showed a plateau greater than 10%. In five ischemic heart disease patients with the net PRP > or = 300 x 10(3) mmHg/min, the exercise WR values were significantly elevated in normal segments relative to ischemic segments. CONCLUSION: BMIPP washout increased with the increase in cardiac work during exercise in normal myocardium but not in ischemic myocardium. A certain amount of exercise is necessary to evaluate fatty acid metabolism in normal and ischemic myocardium. |
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Authors:
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K Takeda; K Saito; K Makino; Y Saito; S Aoki; T Koji; K Matsumura; Y Nomura; T Kitano; T Nakagawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 38 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-05-05 Completed Date: 1997-05-05 Revised Date: 2006-05-06 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 559-63 Citation Subset: IM |
Affiliation:
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Department of Radiology, Mie University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Coronary Disease / physiopathology, radionuclide imaging* Exercise Test* Fatty Acids / diagnostic use* Female Heart / physiopathology, radionuclide imaging* Humans Iodine Radioisotopes / diagnostic use* Iodobenzenes / diagnostic use* Male Middle Aged Thallium Radioisotopes / diagnostic use Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Thallium Radioisotopes; 116754-87-1/iodofiltic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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