Document Detail

Iodine-123-BMIPP myocardial washout and cardiac work during exercise in normal and ischemic hearts.
MedLine Citation:
PMID:  9098201     Owner:  NLM     Status:  MEDLINE    
Iodine-123-BMIPP washout at rest and after exercise was investigated in relation to cardiac work in normal and ischemic myocardium. METHODS: Sixteen healthy volunteers and 10 patients with ischemic heart disease were examined. After injection of 111 MBq of 123I-BMIPP, successive SPECT imaging was performed to evaluate washout ratio (WR) at rest and after mild and maximal exercise. RESULTS: In the healthy volunteers, the mean WR was 3.3 +/- 3.5% after 1 hr of rest and increased during both mild and maximal exercise. The WR showed a better correlation with net pressure rate product (PRP) than with the peak PRP. After maximal exercise, the WR showed a distinct correlation with the net PRP in the range from 200-300 x 10(3) mmHg/min and then showed a plateau greater than 10%. In five ischemic heart disease patients with the net PRP > or = 300 x 10(3) mmHg/min, the exercise WR values were significantly elevated in normal segments relative to ischemic segments. CONCLUSION: BMIPP washout increased with the increase in cardiac work during exercise in normal myocardium but not in ischemic myocardium. A certain amount of exercise is necessary to evaluate fatty acid metabolism in normal and ischemic myocardium.
K Takeda; K Saito; K Makino; Y Saito; S Aoki; T Koji; K Matsumura; Y Nomura; T Kitano; T Nakagawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  38     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-05     Completed Date:  1997-05-05     Revised Date:  2006-05-06    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-63     Citation Subset:  IM    
Department of Radiology, Mie University School of Medicine, Japan.
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MeSH Terms
Coronary Disease / physiopathology,  radionuclide imaging*
Exercise Test*
Fatty Acids / diagnostic use*
Heart / physiopathology,  radionuclide imaging*
Iodine Radioisotopes / diagnostic use*
Iodobenzenes / diagnostic use*
Middle Aged
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Thallium Radioisotopes; 116754-87-1/iodofiltic acid

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