Document Detail


Iodinated contrast agents. Effect on ATP: creatine N-phosphotransferase isoenzymes in arterial wall.
MedLine Citation:
PMID:  6832935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the arterial wall, ATP:creatine N-phosphotransferase (E.C.2.7.3.2) is present in the form of its three isoenzymes, MM, MB, and BB, the latter being predominant. Six iodinated contrast agents in routine angiographic use were examined from the point of view of their effects in vitro on the isoenzymes of ATP:creatine N-phosphotransferase from the arterial wall, compared with their effects on the same isoenzymes in other organs. There is a clear inhibitory effect from the contrast agents on all organs, but it is least marked for the arterial wall. Furthermore, nonionic compounds have far less enzyme-inhibitory effect than ionic compounds.
Authors:
C Canillot; J Etienne; F Borson; J Guidollet; M Amiel; P Louisot
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  18     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:    1983 Jan-Feb
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / drug effects,  enzymology
Arteries / drug effects*,  enzymology
Brain / enzymology
Contrast Media / pharmacology*
Creatine Kinase / metabolism*
Diatrizoate / pharmacology
Dogs
Iopamidol
Iothalamic Acid / analogs & derivatives,  pharmacology
Isoenzymes
Metrizamide / pharmacology
Muscles / enzymology
Myocardium / enzymology
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Isoenzymes; 117-96-4/Diatrizoate; 2276-90-6/Iothalamic Acid; 28179-44-4/ioxitalamic acid; 31112-62-6/Metrizamide; 62883-00-5/Iopamidol; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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