Document Detail


Iodide as an Activating Agent for Acid Chlorides in Acylation Reactions.
MedLine Citation:
PMID:  23342973     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Acid chlorides can be activated using a simple iodide source to undergo nucleophilic attack from a variety of relatively weak nucleophiles. These include Friedel-Crafts acylation of N-methylpyrroles, N-acylation of sulfonamides, and acylation reactions of hindered phenol derivatives. The reaction is believed to proceed through a transient acid iodide intermediate.
Authors:
Russell J Wakeham; James E Taylor; Steven D Bull; James A Morris; Jonathan M J Williams
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, University of Bath , Claverton Down, Bath, BA2 7AY, United Kingdom, and Syngenta Research and Development , Jealott's Hill, Bracknell, RG41 6EY, United Kingdom.
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