| Iodide as an Activating Agent for Acid Chlorides in Acylation Reactions. | |
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MedLine Citation:
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PMID: 23342973 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Acid chlorides can be activated using a simple iodide source to undergo nucleophilic attack from a variety of relatively weak nucleophiles. These include Friedel-Crafts acylation of N-methylpyrroles, N-acylation of sulfonamides, and acylation reactions of hindered phenol derivatives. The reaction is believed to proceed through a transient acid iodide intermediate. |
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Authors:
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Russell J Wakeham; James E Taylor; Steven D Bull; James A Morris; Jonathan M J Williams |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-23 |
Journal Detail:
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Title: Organic letters Volume: - ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, University of Bath , Claverton Down, Bath, BA2 7AY, United Kingdom, and Syngenta Research and Development , Jealott's Hill, Bracknell, RG41 6EY, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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