Document Detail


Iodide Protects Heart Tissue from Reperfusion Injury.
MedLine Citation:
PMID:  25379708     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Iodine is an elemental nutrient that is essential for mammals. Here we provide evidence for an acute therapeutic role for iodine in ischemia reperfusion injury. Infusion of the reduced form, iodide, but not the oxidized form iodate, reduces heart damage by as much as 75% when delivered intravenously following temporary loss of blood flow but prior to reperfusion of the heart in a mouse model of acute myocardial infarction. Normal thyroid function may be required because loss of thyroid activity abrogates the iodide benefit. Given the high degree of protection and the high degree of safety, iodide should be explored further as a therapy for reperfusion injury.
Authors:
Akiko Iwata; Michael L Morrison; Mark B Roth
Related Documents :
25377428 - Protective effect of apigenin on ischemia/reperfusion injury of the isolated rat heart.
25200478 - Caspase-1 transcripts in failing human heart after mechanical unloading.
19451998 - Myocardial tissue characterization based on the time-resolved stokes-mueller formalism.
25370718 - Hemodynamic changes during left ventricular assist device-off test correlate with the d...
20890198 - Predictors of resuscitation in a swine model of ischemic and nonischemic ventricular fi...
15657388 - Role of permanent pacing to prevent atrial fibrillation: science advisory from the amer...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-7
Journal Detail:
Title:  PloS one     Volume:  9     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-7     Completed Date:  -     Revised Date:  2014-11-8    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  -    
Other Details:
Languages:  ENG     Pagination:  e112458     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Modulation of Gene Expression by 3-Iodothyronamine: Genetic Evidence for a Lipolytic Pattern.
Next Document:  Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against ...