Document Detail


Involvment of IL-1 beta Mediated NF-Kappa B Signalling Payhways to Downregulate Prostate Specific Antigen And Cell Proliferation in LNCaP Prostate Cancer Cells.
MedLine Citation:
PMID:  22103356     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: The aim of the present work was to study the involvement of nuclear factor kappa B mediated by Interleukin-1 beta on cell proliferation and Prostate Specific Antigen production of LNCaP prostate cell lines and the possible cross talk with AKT signalling pathway. Methods: Nuclear factor kappa B and AKT were performed by Western Blot analysis from LNCaP cells treated by Interleukin beta. Subsequently, LNCaP cell proliferation and Prostate Specific Antigen production were measured. Results: The treatment of LNCaP cells with Interleukin1 beta inhibited cell proliferation and decreased PSA production. AKT pathway was not sensitive; whereas the phosphorylation of nuclear kappa B was followed by the cytokine's effect. The Prostate Specific Antigen production and the proliferation of LNCaP cells were down regulated by nuclear kappa B mediated by Interleukin1 beta promoting anti-apoptotic signaling and co-suppressor factors of Prostate Specific Antigen expression. Conclusion: Interleukin1 beta through nuclear kappa B activation provides a rationale for therapeutic approaches in the anticancer treatment of prostate.
Authors:
Yosra Bouraoui; Nawfel Ben Rais; Zoran Culig; Ridha Oueslati
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-22
Journal Detail:
Title:  Cell biology international     Volume:  -     ISSN:  1095-8355     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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