Document Detail


Involvement of the upper respiratory tract in orally induced salmonellosis in mice.
MedLine Citation:
PMID:  1092770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The possible involvement of the tissues of the head and neck during the early pathogenesis of orally or intragastrically induced murine salmonellosis was examined. Viable counts of Salmonella in the local lymphoid tissues and draining nodes indicated that the ileal Peyer's patches were primarily involved in the development of a subsequent enteric fever, irrespective of the method of oral challenge. Contamination of drinking water with a high concentration of salmonellae produced infection of the ileal Peyers patches and the eventual development of systemic disease. The cervical lymph nodes were sporadically involved early in the infection, but this involvement soon became general, with large numbers of salmonellae in the cervical nodes by 36 hr. A lower concentration of salmonellae in drinking water led to primary involvement of the ileal Peyers patches; upper respiratory tract involvement was detected much later in the infection. Intragastrically invected mice exhibited the same low-level infection of the cervical lymph nodes as that in mice infected via drinking water. Thus systemic infection apparently results from infection of the ileal Peyers patches; a small percentage of the animals develop a concurrent upper respiratory tract infection that may be responsible for the development of carrier states after enteric infection.
Authors:
P B Carter; J B Woolcock; F M Collins
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  131     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-07-18     Completed Date:  1975-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  570-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Immunization
Liver / microbiology
Lung / microbiology
Male
Mice
Mice, Inbred C57BL
Nasal Cavity / microbiology
Peyer's Patches / microbiology
Respiratory System / microbiology*
Salmonella Infections, Animal / immunology*
Salmonella enteritidis / isolation & purification*
Spleen / microbiology
Stomach

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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