Document Detail

Involvement of two related porins, OprD and OpdP, in the uptake of arginine by Pseudomonas aeruginosa.
MedLine Citation:
PMID:  16790014     Owner:  NLM     Status:  MEDLINE    
The OprD family of specific porins in Pseudomonas aeruginosa comprises 19 members, some of which have been demonstrated to facilitate the uptake of specific compounds into the cell. The members of this family share considerable amino acid sequence similarity (46-57%), which is unusual among porin molecules. In this work, we sought to establish whether this sequence conservation was the basis for other shared aspects of this family. The transcriptional profiles of eight relatively well-characterized OprD homologs were assessed in cells grown on a variety of carbon compounds. The expression of these paralogous proteins correlated with their phylogenetic distribution into two subfamilies in that the three members of the OpdK subfamily were induced by their specific (organic acid) substrates while the five members of the amino-acid/peptide-specific OprD subfamily appeared to be constitutively expressed. Functional overlap with respect to arginine transport was observed between two members of the latter subfamily, the basic amino acid-specific porin, OprD, and the glycine-glutamate-specific porin, OpdP. The impact of this apparent functional redundancy on the genetic fitness of P. aeruginosa is discussed.
Sandeep Tamber; Robert E W Hancock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEMS microbiology letters     Volume:  260     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-22     Completed Date:  2006-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  IM    
Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
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MeSH Terms
Arginine / metabolism*
Gene Expression Profiling
Porins / genetics,  physiology*
Pseudomonas aeruginosa / genetics,  metabolism*
Reg. No./Substance:
0/Porins; 148412-32-2/OprD protein, Pseudomonas aeruginosa; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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