| Involvement and therapeutic potential of the GABAergic system in the fragile X syndrome. | |
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MedLine Citation:
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PMID: 21057732 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Many drugs have been developed that are able to modulate the GABAergic system, which is involved in anxiety, depression, epilepsy, insomnia, and learning and memory. The recent observation that the GABA(A) receptor is underexpressed in the fragile X syndrome, an inherited mental retardation disorder, therefore raised hopes for targeted therapy of the disorder. This review summarizes the lines of evidence that demonstrate a malfunction of the GABAergic system. The GABAergic system clearly emerges as an attractive target for therapy of the fragile X syndrome, and thus provides an excellent example of how genetic research can lead to unique opportunities for treatment. |
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Authors:
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Inge Heulens; Charlotte D'Hulst; Sien Braat; Liesbeth Rooms; R Frank Kooy |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-04 |
Journal Detail:
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Title: TheScientificWorldJournal Volume: 10 ISSN: 1537-744X ISO Abbreviation: ScientificWorldJournal Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101131163 Medline TA: ScientificWorldJournal Country: England |
Other Details:
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Languages: eng Pagination: 2198-206 Citation Subset: IM |
Affiliation:
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Department of Medical Genetics, University of Antwerp, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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