Document Detail

Involvement of src-kinase activation in ischemic preconditioning induced protection of mouse brain.
MedLine Citation:
PMID:  21396377     Owner:  NLM     Status:  Publisher    
Aim To investigate the role of src-kinase in ischemic preconditioning induced reversal of ischemia and reperfusion induced cerebral injury in mice. Main methods Bilateral carotid artery occlusion of 17min followed by reperfusion for 24hr was employed to produce ischemia and reperfusion induced cerebral injury in mice. Cerebral infarct size was measured using triphenyltetrazolium chloride staining using both by volume and by weight methods differently. Memory was evaluated using elevated plus maze test. Rota rod test was employed to assess motor incoordination. Key findings Bilateral carotid artery occlusion followed by reperfusion produced cerebral infarction and impaired memory and motor co-ordination. Three preceding episodes of bilateral carotid artery occlusion for 1min and reperfusion of 1min (ischemic preconditioning) prevented markedly ischemia-reperfusion-induced cerebral injury measured in terms of infarct size (38.5±1.3 % and 38.5±2.9 % mean infarct of control animals was reduced to 24.3±1.2 % and 23.5±1.8 % of the preconditioning groups respectively), loss of memory (72.2±3.6 mean transfer latency time of control animals was reduced to 25.6±5.2 of the preconditioning group respectively) and motor coordination (78.3±17.6sec mean falling down latency time of control animals was increased to a mean value of 180.9±6.5sec of the preconditioning groups respectively). SU6656(2mg/kg, ip) and PP1 (0.1mg/kg, ip), highly selective src-kinase inhibitors, attenuated this neuroprotective effect of ischemic preconditioning. Significance Therefore, neuroprotective effect of ischemic preconditioning may be due to src-kinase linked mechanism.
Ashish K Rehni; Thakur Gurjeet Singh; Tarun Kakkar; Sandeep Arora
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-8
Journal Detail:
Title:  Life sciences     Volume:  -     ISSN:  1879-0631     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier Inc.
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