| Involvement of selective alpha-2 adrenoreceptor in sympathetically maintained pain. | |
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MedLine Citation:
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PMID: 20617085 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: Peripheral nerve injury often leads to neuropathic pain, which is characterized by burning pain, allodynia, and hyperalgesia. The role of the sympathetic nervous system in neuropathic pain is a complex and controversial issue. It is generally accepted that the alpha adrenoreceptor (AR) in sympathetic nerve system plays a significant role in the maintenance of pain. Among alpha adrenoreceptor, alpha-1 receptors play a major role in the sympathetic mediated pain. The primary goal of this study is to test the hypothesis that sympathetically maintained pain involves peripheral alpha-2 receptors in human. METHODS: The study was a randomized, prospective, double-blinded, crossover study involving twenty patients. The treatments were : Yohimbine (30 mg mixed in 500 mL normal saline), and Phentolamine (1 mg/kg in 500 mL normal saline) in 500 mL normal saline at 70 mL/hr initially then titrated. The patients underwent infusions on three different appointments, at least one month apart. Thus, all patients received all 2 treatments. Pain measurement was by visual analogue scale, neuropathic pain questionnaire, and McGill pain questionnaire. RESULTS: There were significant decreases in the visual analogue scale, neuropathic score, McGill pain score of yohimnine, and phentolamine. CONCLUSION: We conclude that alpha-2 adrenoreceptor, along with alpha-2 adrenoreceptor, may be play role in sympathetically maintained pain in human. |
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Authors:
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Chan Hong Park; An Yong; Sang Ho Lee |
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Publication Detail:
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Type: Journal Article Date: 2010-06-30 |
Journal Detail:
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Title: Journal of Korean Neurosurgical Society Volume: 47 ISSN: 1598-7876 ISO Abbreviation: J Korean Neurosurg Soc Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101467054 Medline TA: J Korean Neurosurg Soc Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 420-3 Citation Subset: - |
Affiliation:
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Department of Anesthesiology and Pain Medicine, Daegu Wooridul Hospital, Daegu, Korea. |
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