| Involvement of prolactin releasing peptide in activation of oxytocin neurones in response to food intake. | |
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MedLine Citation:
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PMID: 23363338 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Food intake activates neurones expressing prolactin releasing peptide (PrRP) in the medulla oblongata and oxytocin neurones in the hypothalamus. Both PrRP and oxytocin have been shown to have an anorexic action. Here, we investigated whether activation of oxytocin neurones following food intake is mediated by PrRP. We first examined expression of PrRP receptors (also known as GPR10) in rats. Immunoreactivity of PrRP receptors was observed in oxytocin neurones and in vasopressin neurones in the paraventricular and supraoptic nuclei of the hypothalamus and in the bed nucleus of the stria terminalis. Application of PrRP to isolated supraoptic nuclei facilitated release of oxytocin and vasopressin. In mice, re-feeding increased expression of Fos protein in oxytocin neurones of the hypothalamus and bed nucleus of the stria terminalis. The increased expression of Fos protein in oxytocin neurones following re-feeding or intraperitoneal administration of cholecystokinin octapeptide (CCK), a peripheral satiety factor, was impaired in PrRP-deficient mice. CCK-induced oxytocin increase in plasma was also impaired in PrRP-deficient mice. Furthermore, oxytocin receptor-deficient mice showed increased meal size, as reported in PrRP-deficient mice and in CCK(A) receptor-deficient mice. These findings suggest that PrRP mediates, at least in part, activation of oxytocin neurones in response to food intake, and that the CCK-PrRP-oxytocin pathway plays an important role in the control of termination of each meal. © 2013 British Society for Neuroendocrinology. |
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Authors:
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Masako Yamashita; Yuki Takayanagi; Masahide Yoshida; Katsuhiko Nishimori; Mikio Kusama; Tatsushi Onaka |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-31 |
Journal Detail:
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Title: Journal of neuroendocrinology Volume: - ISSN: 1365-2826 ISO Abbreviation: J. Neuroendocrinol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913461 Medline TA: J Neuroendocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2013 British Society for Neuroendocrinology. |
Affiliation:
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Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Shimotsuke-shi, Tochigi-ken, Japan; Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Shimotsuke-shi, Tochigi-ken, Japan. |
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