| Involvement of the parabrachial nucleus in thermogenesis induced by environmental cooling in the rat. | |
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MedLine Citation:
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PMID: 12838424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The parabrachial nucleus (PBN), an integration site for autonomic regulation in the mesopontine brainstem, receives sensory information about cold temperatures from the skin. Here we investigated the role of the PBN in thermoregulation. Unilateral stimulation of the PBN (10-40 microA, 5 min) immediately increased the rate of O(2) consumption ( VO(2)) and heart rate, and the magnitude of these responses increased with the intensity of the stimulus in urethane-anesthetized rats. High-intensity (40 microA) stimulation of the PBN increased the temperature of the interscapular brown adipose tissue and that of the colon but had no effect on that of the tail skin, although weaker stimulation was without effect on these temperatures. Next, we examined the effects of bilateral lesioning of the PBN on environmental cooling-induced thermogenesis in conscious rats. Exposure of PBN-lesioned rats to a cool (16.6 degrees C) environment induced a significantly smaller increase in VO(2) than did that of rats with a sham operation or with lesions made outside of the PBN, and resulted in a marked decrease in body temperature in PBN-lesioned rats but not in other rats. Both frequency and duration of gross motor activity in the cool environment were similar between PBN-lesioned and sham-operated rats. These results suggest that the PBN is involved in the central mechanisms of cooling-induced thermogenesis. |
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Authors:
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Akiko Kobayashi; Toshimasa Osaka |
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Publication Detail:
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Type: Journal Article Date: 2003-06-28 |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 446 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-23 Completed Date: 2004-06-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 760-5 Citation Subset: IM |
Affiliation:
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National Institute of Health and Nutrition, 1-23-1 Toyama, 162-8636, Shinjuku, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Body Temperature / physiology Cold Temperature* Electric Stimulation Environment Heart Rate / physiology Male Oxygen Consumption / physiology Pons / physiology* Rats Rats, Wistar Stereotaxic Techniques Thermogenesis / physiology* |
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