| Involvement of oxytocin in the nucleus tractus solitarii on central cardiovascular control: interactions with glutamate. | |
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MedLine Citation:
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PMID: 20228416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxytocin (OT) is a peptide involved in several physiological functions in the central nervous system including central cardiovascular regulation. To clarify the role of endogenous OT in cardiovascular control, one group of anesthetized rats received unilateral microinjections of the OT receptor antagonist [d(CH(2))(5),Tyr(Me)(2),Orn(8)]-vasotocin (OTA) in the nucleus tractus solitarii (NTS) and a second group was injected with specific OT antiserum (Anti-OT). Moreover, the modulation of the cardiovascular effect of L-glutamate (GLU) by OT was also evaluated by cardiovascular analysis using effective and threshold doses of GLU. Mean arterial pressure (MAP) and heart rate (HR) were measured from a femoral catheter. OTA significantly (p<0.01) decreased the vasopressor and tachycardiac long-lasting response elicited by an effective dose of OT. Microinjections of Anti-OT antibody did not modify the values of MAP and HR compared with the control group. With regard to the OT/GLU coinjections, a subthreshold dose of OT significantly (p<0.001) counteracted the vasodepressor and bradycardiac responses induced by GLU. The coinjection of subthreshold doses of OT and GLU did not produce a change in MAP or in HR. These findings seem to exclude an endogenous tonic action of OT on central regulation of MAP and HR, although they confirm the significant role of OT on central cardiovascular control within the NTS. In fact, the modulation of GLU responses by OT supports the importance of OT on the central cardiovascular adjustments likely acting on the baroreceptor reflex sensitivity. |
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Authors:
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C Vela; Z Diaz-Cabiale; C Parrado; M Narvaez; R Covenas; J A Narvaez |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 61 ISSN: 1899-1505 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-10-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 59-65 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Malaga, Malaga, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Baroreflex / drug effects, physiology Blood Pressure / drug effects, physiology* Glutamic Acid / metabolism* Heart Rate / drug effects, physiology* Immune Sera / administration & dosage Male Microinjections Oxytocin / administration & dosage, analogs & derivatives, immunology, physiology* Rats Rats, Sprague-Dawley Receptors, Oxytocin / antagonists & inhibitors Solitary Nucleus / drug effects, metabolism, physiology* Vasotocin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Immune Sera; 0/Receptors, Oxytocin; 50-56-6/Oxytocin; 56-86-0/Glutamic Acid; 77327-45-8/oxytocin,1-(beta-mercapto-(beta, beta-cyclopentamethylene)propionic acid)-Tyr(OMe)(2)-Orn(8)-; 9034-50-8/Vasotocin |
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