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Involvement of oxidatively damaged DNA and repair in cancer development and aging.
MedLine Citation:
PMID:  20589166     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
DNA damage and DNA repair may mediate several cellular processes, like replication and transcription, mutagenesis and apoptosis and thus may be important factors in the development and pathology of an organism, including cancer. DNA is constantly damaged by reactive oxygen species (ROS) and reactive nitrogen species (RNS) directly and also by products of lipid peroxidation (LPO), which form exocyclic adducts to DNA bases. A wide variety of oxidatively-generated DNA lesions are present in living cells. 8-oxoguanine (8-oxoGua) is one of the best known DNA lesions due to its mutagenic properties. Among LPO-derived DNA base modifications the most intensively studied are ethenoadenine and ethenocytosine, highly miscoding DNA lesions considered as markers of oxidative stress and promutagenic DNA damage. Although at present it is impossible to directly answer the question concerning involvement of oxidatively damaged DNA in cancer etiology, it is likely that oxidatively modified DNA bases may serve as a source of mutations that initiate carcinogenesis and are involved in aging (i.e. they may be causal factors responsible for these processes). To counteract the deleterious effect of oxidatively damaged DNA, all organisms have developed several DNA repair mechanisms. The efficiency of oxidatively damaged DNA repair was frequently found to be decreased in cancer patients. The present work reviews the basis for the biological significance of DNA damage, particularly effects of 8-oxoGua and ethenoadduct occurrence in DNA in the aspect of cancer development, drawing attention to the multiplicity of proteins with repair activities.
Authors:
Barbara Tudek; Alicja Winczura; Justyna Janik; Agnieszka Siomek; Marek Foksinski; Ryszard Oliński
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Publication Detail:
Type:  Journal Article     Date:  2010-05-15
Journal Detail:
Title:  American journal of translational research     Volume:  2     ISSN:  1943-8141     ISO Abbreviation:  Am J Transl Res     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-08-12     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101493030     Medline TA:  Am J Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  254-84     Citation Subset:  -    
Affiliation:
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Institute of Genetics and Biotechnology,Warsaw University, Poland. tudek@ibb.waw.pl
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