| Involvement of the ophthalmic artery in giant cell arteritis visualized by 3T MRI. | |
| | |
MedLine Citation:
|
PMID: 19233887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To retrospectively analyse inflammatory involvement of the ophthalmic arteries in patients with GCA utilizing high-resolution MRI. METHODS: A cohort of 50 patients with GCA who had been examined by 1.5 or 3T high-field MRI was analysed retrospectively in a consensus reading for possible involvement of the ophthalmic arteries. In 43 patients, entire orbits were within the field of view. In all cases, the superficial cranial arteries displayed mural inflammation in post-contrast T1-weighted spin-echo (SE) images. MRI results were compared with ophthalmological findings, subjective visual symptoms and laboratory values, i.e. CRP and ESR. RESULTS: We observed mural contrast enhancement of the ophthalmic arteries in 20/43 patients (46%). Bilateral involvement was seen in 14, unilateral enhancement in six cases. Fifteen patients had ophthalmic vascular diseases: nine had anterior ischaemic optic neuropathy (AION), one posterior ischaemic optic neuropathy (PION), four revealed central retinal artery occlusion (CRAO) and one patient presented with narrowing of the retinal arteries. Funduscopy detected no arteritis-related changes in 22 cases. Of those patients who were MRI positive, seven had ophthalmological disease. Twenty-six patients complained of visual symptoms including amaurosis fugax, vision loss, diplopia or eye pain. CONCLUSIONS: High-resolution MRI detects mural contrast enhancement consistent with inflammatory changes in the superficial cranial and extracranial arteries and additionally in the ophthalmic arteries. This provides insight in vasculitic orbital involvement during one single investigation. |
| | |
Authors:
|
Julia Geiger; Thomas Ness; Markus Uhl; Wolf A Lagrèze; Peter Vaith; Mathias Langer; Thorsten A Bley |
Related Documents
:
|
15143227 - Gadolinium-enhanced three-dimensional mr angiography of takayasu arteritis. 16329047 - The role of ultrasound biomicroscopy in predicting the result of temporal artery biopsy... 16607057 - Usefulness of fluorine-18-fluorodeoxyglucose positron emission tomography in a patient ... 18504527 - Takayasu disease with prominent pulmonary artery involvement: confusion with pulmonary ... 21304427 - Doppler ultrasonography and ct angiography demonstrate positional occlusion of vertebra... 15143227 - Gadolinium-enhanced three-dimensional mr angiography of takayasu arteritis. |
Publication Detail:
|
Type: Journal Article Date: 2009-02-20 |
Journal Detail:
|
Title: Rheumatology (Oxford, England) Volume: 48 ISSN: 1462-0332 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-17 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
|
Languages: eng Pagination: 537-41 Citation Subset: AIM; IM |
Affiliation:
|
Department of Radiology, University of Freiburg, Freiburg, Germany. julia.geiger@uniklinik-freiburg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Biopsy Female Giant Cell Arteritis / diagnosis*, pathology Humans Magnetic Resonance Imaging / methods Male Middle Aged Ophthalmic Artery / pathology* Optic Neuropathy, Ischemic / diagnosis Retinal Artery Occlusion / diagnosis Retrospective Studies Temporal Arteries / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Renal damage is the most important predictor of mortality within the damage index: data from LUMINA ...
Next Document: Escape rhythm from a partially disconnected pulmonary vein.