| Involvement of omega-3 fatty acids in emotional responses and hyperactive symptoms. | |
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MedLine Citation:
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PMID: 20434321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biochemical evidence suggests a role for n-3 polyunsaturated fatty acids (n-3 PUFAs) in the regulation of behavioral disturbances. A number of studies have revealed an association between reduced n-3 PUFA levels and attention-deficit hyperactivity disorder or depression. Here, we summarize the main findings regarding the association between n-3 PUFA and hyperactive and emotional disorders, and discuss potential mechanisms of action. Because the basal ganglia are involved in the control of locomotion and emotion, we examined published data regarding the role of n-3 PUFA in dopamine (DA) regulation in the basal ganglia. These results are discussed in the light of recent data from our laboratory suggesting an association between the drop in melatonin in the pineal gland and the increase in DA in the striatum and nucleus accumbens of n-3 PUFA-deprived rodents. |
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Authors:
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Monique Lavialle; Isabelle Denis; Philippe Guesnet; Sylvie Vancassel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 21 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 899-905 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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INRA, UR 909 Nutrition et Régulation Lipidique des Fonctions Cérébrales, F-78352 Jouy-en-Josas, France. monique.lavialle@jouy.inra.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Attention Deficit Disorder with Hyperactivity / prevention & control* Brain / drug effects Dietary Fats Emotions* Fatty Acids, Omega-3 / pharmacology* Humans |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids, Omega-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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