Document Detail

Involvement of omega-3 fatty acids in emotional responses and hyperactive symptoms.
MedLine Citation:
PMID:  20434321     Owner:  NLM     Status:  MEDLINE    
Biochemical evidence suggests a role for n-3 polyunsaturated fatty acids (n-3 PUFAs) in the regulation of behavioral disturbances. A number of studies have revealed an association between reduced n-3 PUFA levels and attention-deficit hyperactivity disorder or depression. Here, we summarize the main findings regarding the association between n-3 PUFA and hyperactive and emotional disorders, and discuss potential mechanisms of action. Because the basal ganglia are involved in the control of locomotion and emotion, we examined published data regarding the role of n-3 PUFA in dopamine (DA) regulation in the basal ganglia. These results are discussed in the light of recent data from our laboratory suggesting an association between the drop in melatonin in the pineal gland and the increase in DA in the striatum and nucleus accumbens of n-3 PUFA-deprived rodents.
Monique Lavialle; Isabelle Denis; Philippe Guesnet; Sylvie Vancassel
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of nutritional biochemistry     Volume:  21     ISSN:  1873-4847     ISO Abbreviation:  J. Nutr. Biochem.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010081     Medline TA:  J Nutr Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  899-905     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
INRA, UR 909 Nutrition et Régulation Lipidique des Fonctions Cérébrales, F-78352 Jouy-en-Josas, France.
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / prevention & control*
Brain / drug effects
Dietary Fats
Fatty Acids, Omega-3 / pharmacology*
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Omega-3

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