| Involvement of nitrosative stress in experimental periodontitis in diabetic rats. | |
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MedLine Citation:
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PMID: 22276937 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: Periodontal disease is highly prevalent and severe in diabetic patients, and is considered one of the diabetic complications. To elucidate how periodontitis progresses in diabetes, we examined an animal model of periodontitis in diabetic rats. MATERIALS AND METHODS: Two weeks after the induction of diabetes by streptozotocin, surgical nylon thread was ligated around the cervical portion of the unilateral maxillary second molar to induce periodontitis. Periodontitis was evaluated 2 weeks after the ligation by gingival blood flow, mRNA expressions, Western blot analysis, histological examination and micro CT. RESULTS: Ligation-induced severe periodontitis in the diabetic rats, which was apparently shown by the increase of TNF-α and iNOS mRNA expressions and inflammatory cell infiltration in the gingiva and alveolar bone loss. The number of nitrotyrosine, a footprint of nitrosative stress, -positive cells was significantly higher in the periodontitis of the diabetic rats compared with that in the normal rats. Western blot analysis confirmed that the nitrotyrosine was increased in the periodontitis of the diabetic rats. CONCLUSIONS: This is the first study to confirm increased nitrosative stress due to periodontitis in diabetic rats. Nitrosative stress may play a crucial role in the exacerbation of periodontitis in diabetic patients. |
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Authors:
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Toru Nishikawa; Keiko Naruse; Yasuko Kobayashi; Shinichi Miyajima; Makoto Mizutani; Takeshi Kikuchi; Kyoko Soboku; Nobuhisa Nakamura; Asako Sokabe; Takahiro Tosaki; Masaki Hata; Norikazu Ohno; Toshihide Noguchi; Tatsuaki Matsubara |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-26 |
Journal Detail:
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Title: Journal of clinical periodontology Volume: - ISSN: 1600-051X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425123 Medline TA: J Clin Periodontol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Periodontology. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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