| Involvement of the miR17 pathway in glucocorticoid -induced cell death in pediatric acute lymphoblastic leukemia. | |
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MedLine Citation:
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PMID: 22475310 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Analysis of the microRNA transcriptome following dexamethasone treatment of the acute lymphocytic leukemia (ALL) cell line RS4;11 showed a global down-regulation of microRNA levels. MIR17HG was rapidly down-regulated following treatment, with ChIP analysis demonstrating the promoter to be a direct target of GC-transcriptional repression and revealing the miR17-92 cluster as a prime target for dexamethasone-induced repression. The loss of miR17 family expression and concomitant increases in the miR17 target Bim occurred in an additional ALL cell line SUP-B15 but not in the dexamethasone-resistant REH Alteration of miR17 levels through upregulation or inhibition resulted in the decrease and increase, respectively, in Bim protein levels and dexamethasone-induced cell death. Primary ex vivo ALL cells that underwent apoptosis induced by dexamethasone also down-regulated miR17 levels. Thus, down-regulation of miR17 plays an important role in glucocorticoid-induced cell death suggesting that targeting miR17 may improve the current ALL combination therapy. |
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Authors:
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Masako Harada; Katja Pokrovskaja Tamm; Stefan Söderhäll; Mats Heyman; Dan Grander; Martin Corcoran |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-4 |
Journal Detail:
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Title: Leukemia & lymphoma Volume: - ISSN: 1029-2403 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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