| Involvement of matrix metalloproteinase-2 in medial hypertrophy of pulmonary arterioles in broiler chickens with pulmonary arterial hypertension. | |
| | |
MedLine Citation:
|
PMID: 22377328 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Medial hypertrophy of pulmonary arterioles during pulmonary arterial hypertension (PAH) in humans is associated with enhanced proliferation of smooth muscle cells (SMCs). Elevated matrix metalloproteinase (MMP)-2 has been found in pulmonary artery SMCs (PA-SMCs) in humans with idiopathic PAH, leading to the hypothesis that MMP-2 contributes to the proliferation and migration of vascular SMCs in the pathogenesis of PAH. Rapidly growing meat-type (broiler) chickens provide a model of spontaneous PAH. The present study was conducted to determine whether MMP-2 is involved in the medial hypertrophy of pulmonary arterioles in this model. Cultured PA-SMCs from normal birds were used to evaluate the effect of MMPs on cell proliferation. Gelatin zymography showed that endothelin (ET)-1-induced proliferation of PA-SMCs was concomitant with increased pro- and active MMP-2 production. Reverse transcription PCR demonstrated upregulation of MMP-2 mRNA. However, PA-SMC proliferation was inhibited by the MMP inhibitors doxycycline and cis-9-octadecenoyl-N-hydroxylamide. In vivo experiments revealed a significant increase of MMP-2 expression in hypertrophied pulmonary arterioles of PAH broiler chickens, which was positively correlated with wall thickness and medial hypertrophy. MMP-2 may contribute to medial hypertrophy in pulmonary arterioles during PAH in broiler chickens by enhancing the proliferation of vascular SMCs. |
| | |
Authors:
|
Xun Tan; Juan Chai; Shi-Cheng Bi; Jun-Jun Li; Wen-Wen Li; Ji-Yong Zhou |
Related Documents
:
|
12950548 - Complete occlusion of the left circumflex coronary artery after radiofrequency catheter... 15216088 - Disc variance of the harken mitral prosthesis: the contribution of associated aortic re... 21631638 - Photoinduced collagen cross-linking: a new approach to venous insufficiency. 7671278 - Left ventricular-coronary sinus fistula after mitral valve replacement: diagnosis by tr... 9012998 - Advances in the surgical repair of ruptured abdominal aortic aneurysms. 10348458 - Mathematical analysis of arterial enhancement and optimization of bolus geometry for ct... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-27 |
Journal Detail:
|
Title: Veterinary journal (London, England : 1997) Volume: - ISSN: 1532-2971 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9706281 Medline TA: Vet J Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Key Laboratory of Animal Virology of Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intestinal barrier function in neonatal foals: Options for improvement.
Next Document: Unilateral autoscopic phenomena as a lateralizing sign in focal epilepsy.