| Involvement of the lodothyronines in liver and hepatoma cell proliferation in the rat. | |
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MedLine Citation:
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PMID: 7388800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3,3',5-Triiodo-L-thyronine (200 microgram/100 g) is shown to be a potent liver parenchymal cell mitogen in the rat, and thyroidectomy is seen to severely inhibit hepatocyte proliferation in regenerating rat liver. Taken together, these observations point to a crucial role for the iodothyronine in liver cell hyperplasia. The growth rates of the transplantable Morris hepatomas 7777 and 5123tc are shown to be retarded in the surgically thyroidectomized-parathyroidectomized rat. This inhibition of tumor growth can be reversed by thyroid hormone administration. It has earlier been observed that the hypothyroid state induced in the rat by administration of propylthiouracil or radioactive iodine retarded the growth of the transplanted Morris hepatomas 7800 and 44, suggesting that these tumors were also thyroid dependent. Our results suggest that the thyroid hormones may play a similar role in the growth of liver cell-derived cancers as they do in normal hepatocyte proliferation. |
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Authors:
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J Short; K Klein; L Kibert; P Ove |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 40 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1980 Jul |
Date Detail:
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Created Date: 1980-09-28 Completed Date: 1980-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2417-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA / biosynthesis DNA Replication Female Hepatectomy Liver / metabolism* Liver Neoplasms, Experimental / metabolism, pathology* Liver Regeneration Male Neoplasm Transplantation Rats Rats, Inbred BUF Thyroid Gland / metabolism* Thyroidectomy Triiodothyronine / metabolism*, pharmacology |
| Chemical | |
Reg. No./Substance:
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6893-02-3/Triiodothyronine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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