| Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training. | |
| | |
MedLine Citation:
|
PMID: 22093827 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
It is well known that exercise prevents and reduces cognitive impairment. In the present study, we focused on exercise training as a tool to prevent cognitive impairment, and searched for novel molecules that may relate to the prevention of cognitive impairment in the hippocampus. Two-month-old senescence-accelerated mouse prone-8 (SAMP8) mice were subjected to voluntary exercise training by running on a wheel for 4months, and were then assigned a conditioned fear memory test. Moreover, various mRNA levels in the hippocampus were examined by DNA array analysis and real-time PCR. Contextual fear memory in SAMP8 control mice was significantly impaired compared with that in non-senescence mice. Exercise training definitely attenuated such cognitive impairment. The results of real-time PCR analysis that was conducted following DNA array analysis in the hippocampus revealed that, compared with SAMR8 control mice, the expression levels of leucine zipper transcription factor-like protein 1 (Lztfl1) mRNA were significantly higher in SAMP8 mice subjected to exercise training. In addition, the overexpression of Lztfl1 promoted neurite outgrowth in Neuro 2a cells. These results suggest that exercise has a preventive effect on cognitive impairment in SAMP8 mice, and that exercise-induced increase in Lztfl1 induces neurite outgrowth. |
| | |
Authors:
|
Takuya Sakurai; Junetsu Ogasawara; Takako Kizaki; Yoshinaga Ishibashi; Tomonori Fujiwara; Kimio Akagawa; Tetsuya Izawa; Shuji Oh-Ishi; Shukoh Haga; Hideki Ohno |
Related Documents
:
|
3229117 - Deep vein thrombosis and its prevention in patients with acute myocardial infarction. 22154397 - Is the six-minute walk test appropriate for detecting changes in cardiorespiratory fitn... 22158097 - Rapid increase in training load affects markers of skeletal muscle damage and mechanica... 7283557 - National exercise and heart disease project. psychosocial changes observed during a low... 8205747 - Biochemical changes in relation to a maximal exercise test in patients with fibromyalgia. 15579557 - Lactate availability is not the major factor limiting muscle glycogen repletion during ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-11 |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: - ISSN: 1090-2104 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
|
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transgenic overexpression of bone morphogenetic protein 11 propeptide in skeleton enhances bone form...
Next Document: Characterisation and comparison of the chicken H1 RNA polymerase III promoter for short hairpin RNA ...