Document Detail

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis.
MedLine Citation:
PMID:  19684581     Owner:  NLM     Status:  MEDLINE    
T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.
Roberta Caruso; Elisabetta Botti; Massimiliano Sarra; Maria Esposito; Carmine Stolfi; Laura Diluvio; Maria Laura Giustizieri; Valentina Pacciani; Annamaria Mazzotta; Elena Campione; Thomas T Macdonald; Sergio Chimenti; Francesco Pallone; Antonio Costanzo; Giovanni Monteleone
Publication Detail:
Type:  Journal Article     Date:  2009-08-16
Journal Detail:
Title:  Nature medicine     Volume:  15     ISSN:  1546-170X     ISO Abbreviation:  Nat. Med.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-07     Completed Date:  2009-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502015     Medline TA:  Nat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1013-5     Citation Subset:  IM    
Gastroenterology, University Tor Vergata of Rome, Rome, Italy.
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MeSH Terms
Case-Control Studies
Cell Proliferation / drug effects
Disease Models, Animal
Interleukins / antagonists & inhibitors,  genetics,  pharmacology,  physiology*
Keratinocytes / drug effects,  immunology,  pathology,  transplantation
Psoriasis / genetics,  immunology*,  pathology,  therapy
RNA, Messenger / genetics,  metabolism
Recombinant Proteins / pharmacology
T-Lymphocytes / immunology
Transplantation, Heterologous
Reg. No./Substance:
0/Interleukins; 0/RNA, Messenger; 0/Recombinant Proteins; 0/interleukin-21

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