Document Detail


Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats.
MedLine Citation:
PMID:  24700389     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
RATIONALE: Drug addiction represents a pathological usurpation of neural processes involved in learning and memory. Retrieval of drug-related memories can result in drug craving and relapse. Recently, the insula was identified as part of the neuronal circuit responsible for the processing of drug memory; however, its precise role remains unclear.
OBJECTIVE: To investigate the involvement of insular muscarinic acetylcholine receptors (mAChRs) in the processing of drug memory.
METHOD: The morphine-induced conditioned place preference (CPP) was used to assess drug memory. All rats were first trained with morphine to establish the CPP. Sub-groups of these rats were used for contextual cue-induced CPP reinstatement. Other sub-groups of rats underwent extinction of the CPP, and 5 m/kg morphine was used for priming-induced CPP reinstatement. Microinjection of mAChR antagonists or agonists into the insula was performed prior to the CPP tests in order to evaluate their effect on CPP expression.
RESULTS: Insular microinjections of the nonselective mAChR antagonist, scopolamine, and the M1 antagonist, pirenzepine, significantly inhibited CPP expression in both contextual cue- and priming-induced CPP reinstatement; the M1 agonist, MCN-A-343, and the M4 antagonist, tropicamide, enhanced CPP expression. The M4 agonist, LY2033298, inhibited CPP expression. The M2 antagonist, methoctramine, and M3 antagonist, 4-DAMP, had no effect on CPP expression.
CONCLUSION: Our results demonstrate that insular mAChRs play a role in the processing of drug memory. M1 and M4 mAChRs work paradoxically; M1 activation and M4 inhibition attenuate the expression of drug memory, while M1 inhibition and M4 activation augment the expression of drug memory.
Authors:
Wei Wu; Hui Li; Yu Liu; Xinjie Huang; Lei Chen; Haifeng Zhai
Related Documents :
6936969 - Antileukemic activity of 4-demethoxydaunorubicin in mice.
1672379 - Effect of neurotransmitter-selective drugs in mice selected for differential sensitivit...
14704469 - Influence of sib 1893, a selective mglur5 receptor antagonist, on the anticonvulsant ac...
12412759 - Synergistic effects of locally administered cytostatic drugs and a surfactant on the de...
19945679 - Mice as a model for homeopathy research.
1129259 - Infantile auditory exposure and unusual response to antipsychiotic drugs (38510).
7648659 - Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated th...
22074279 - Conference report: the importance of ht-adme in drug discovery.
16376469 - Cadmium and lead concentrations in skrjabinotaenia lobata (cestoda: catenotaeniidae) an...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-4
Journal Detail:
Title:  Psychopharmacology     Volume:  -     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fluoxetine: juvenile pharmacokinetics in a nonhuman primate model.
Next Document:  Disrupting the methionine biosynthetic pathway in Candida guilliermondii: characterization of the ME...