| Involvement of the human cerebellum in fear-conditioned potentiation of the acoustic startle response: a PET study. | |
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MedLine Citation:
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PMID: 12151786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fear-conditioned potentiation of the startle response was used to study the role of the cerebellum in associative learning of non-specific aversive reactions in healthy human subjects using PET. Prior PET scanning initially neutral light stimuli were paired with painful electric shocks (fear-conditioning phase). Four PET-scans each were performed with presentation of acoustic startle stimuli (T), fear-conditioned light stimuli (L) or acoustic stimuli paired with light (LT, potentation phase). As a measure of fear-conditioning subtraction of condition T from LT revealed an increase of regional cerebellar blood flow (rCBF) in the left cerebellar hemisphere. Subtraction of condition L from LT, as a measure of fear-conditioned potentiation, revealed an increase of rCBF in the medial cerebellum. Different parts of the cerebellum appear to be involved in this form of motor associative learning. |
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Authors:
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Markus Frings; Matthias Maschke; Maren Erichsen; Walter Jentzen; Stefan P Müller; Florian P Kolb; Hans-Christoph Diener; Dagmar Timmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 13 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-08-01 Completed Date: 2002-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1275-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Adult Association Learning / physiology Cerebellum / blood supply, physiology* Conditioning (Psychology) / physiology Fear / physiology* Humans Male Startle Reaction / physiology* Tomography, Emission-Computed* |
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