Document Detail

Involvement of the human cerebellum in fear-conditioned potentiation of the acoustic startle response: a PET study.
MedLine Citation:
PMID:  12151786     Owner:  NLM     Status:  MEDLINE    
Fear-conditioned potentiation of the startle response was used to study the role of the cerebellum in associative learning of non-specific aversive reactions in healthy human subjects using PET. Prior PET scanning initially neutral light stimuli were paired with painful electric shocks (fear-conditioning phase). Four PET-scans each were performed with presentation of acoustic startle stimuli (T), fear-conditioned light stimuli (L) or acoustic stimuli paired with light (LT, potentation phase). As a measure of fear-conditioning subtraction of condition T from LT revealed an increase of regional cerebellar blood flow (rCBF) in the left cerebellar hemisphere. Subtraction of condition L from LT, as a measure of fear-conditioned potentiation, revealed an increase of rCBF in the medial cerebellum. Different parts of the cerebellum appear to be involved in this form of motor associative learning.
Markus Frings; Matthias Maschke; Maren Erichsen; Walter Jentzen; Stefan P Müller; Florian P Kolb; Hans-Christoph Diener; Dagmar Timmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  13     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-08-01     Completed Date:  2002-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1275-8     Citation Subset:  IM    
Department of Neurology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany.
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MeSH Terms
Acoustic Stimulation
Association Learning / physiology
Cerebellum / blood supply,  physiology*
Conditioning (Psychology) / physiology
Fear / physiology*
Startle Reaction / physiology*
Tomography, Emission-Computed*

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