Document Detail


Involvement of herb-herb interactions in the influences of Radix Scutellaria and Coptis Chinensis on the bioavailability of the anthraquinones form Rhei Rhizoma in rats.
MedLine Citation:
PMID:  24659524     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Xiexin decoction (XXD) is composed of Rhei Rhizoma (DH), Radix Scutellaria (HQ), and Coptis Chinensis (HL). Free anthraquinones in DH are the basic effective constituents in XXD. Reportedly, HL decreases the bioavailability of the anthraquinones, while HQ antagonizes the effect of HL. In this study, we aimed to determine the underlying mechanisms. The metabolisms of anthraquinones by intestinal flora were studied using rat fecal suspension (RFS); the metabolisms of rhein (a typical anthraquinone in DH) by rat intestine and liver were studied using rat intestine microsomes (RIMs) and rat liver microsomes (RLMs), respectively; the intestinal transport of rhein was studied using everted gut sacs. The results showed that HL decreased the amount of the free anthraquinones after incubation in RFS and inhibited the intestinal transport of rhein, but HQ antagonized the effect of HL. On the other hand, HQ strongly inhibited the glucuronidation of rhein in both RIMs and RLMs. The results suggested that HL decreased the oral bioavailability of the anthraquinones due to inhibiting the conversion of conjugated anthraquinones to free anthraquinones by intestinal flora and decreasing the intestinal transport of the anthraquinones; HQ confronted the effect of HL by inhibiting the glucuronidation of the anthraquinones in intestine and weakening the inhibitory effects of HL.
Authors:
Dongming Yan; Bingliang Ma; Rong Shi; Tianming Wang; Yueming Ma
Related Documents :
19821814 - The effect of lyophilization on graft acceptance in experimental xenotransplantation us...
3143654 - Prolonged intratesticular islet allograft survival is not dependent on local steroidoge...
18511434 - Ap-1 and stat-1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat ca...
8353464 - Alteration in t cell subset phenotypes as cell markers for rejection or long-term allog...
20804604 - Perinatal taurine exposure alters renal potassium excretion mechanisms in adult conscio...
15870904 - Increased myocardial n-myristoyltransferase activity in rotenone model of parkinsonism.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-22
Journal Detail:
Title:  European journal of drug metabolism and pharmacokinetics     Volume:  -     ISSN:  0378-7966     ISO Abbreviation:  Eur J Drug Metab Pharmacokinet     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608491     Medline TA:  Eur J Drug Metab Pharmacokinet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of calcium phosphate composition in sputter coatings on in vitro and in vivo performance.
Next Document:  Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory pr...