Document Detail


Involvement of the heme oxygenase system in the development of preeclampsia and as a possible therapeutic target.
MedLine Citation:
PMID:  25482489     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The enzyme heme oxygenase (HO) is an important regulatory molecule present in most nucleated mammalian cells which functions to break down the pro-oxidant molecule heme into three products, carbon monoxide (CO), biliverdin and free iron. The HO system has been associated with many physiologic functions, including vascular tone, regulation of inflammation and apoptosis, angiogenesis and antioxidant capabilities. Deficiencies in HO are associated with several pregnancy disorders, including preeclampsia. With no present cure, this disorder continues to affect 5-7% of all pregnancies worldwide, leading to maternal and fetal morbidity and mortality. Researchers continue to strive for therapeutic potentials and this review will outline the possible use of the HO/CO system as a target treatment/prevention of preeclampsia in the future.
Authors:
Carolina C Venditti; Graeme N Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Women's health (London, England)     Volume:  10     ISSN:  1745-5065     ISO Abbreviation:  Womens Health (Lond Engl)     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271249     Medline TA:  Womens Health (Lond Engl)     Country:  England    
Other Details:
Languages:  eng     Pagination:  623-43     Citation Subset:  IM    
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