Document Detail

Involvement of the heart by small and medium vessel vasculitis.
MedLine Citation:
PMID:  19077715     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The heart may be involved in many different ways by the systemic vasculitides. In this review, we focus on recently described diagnostic and therapeutic issues in small and medium vessel vasculitis of the heart. RECENT FINDINGS: Data have emerged on the prevalence and significance of cardiac involvement in the systemic vasculitides. There is an increasing array of sophisticated imaging modalities including echocardiography, PET, and cardiac MRI that aid in the clinical diagnosis. SUMMARY: Most small and medium vessel vasculitides may involve the heart; however, the mode and incidence of cardiac involvement vary with the different vasculitic syndromes. This review describes the various cardiac manifestations of small and medium vessel vasculitis and the advantages of modern imaging modalities including echocardiography, MRI, and PET coupled with biologic biomarkers such as brain natriuretic peptide and antineutrophilic cytoplasmic antibodies in the diagnosis and management of disease.
Garvan C Kane; Karina A Keogh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  21     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-34     Citation Subset:  IM    
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Churg-Strauss Syndrome / diagnosis,  pathology,  physiopathology
Diagnostic Imaging / methods*
Heart / physiopathology*
Heart Valve Diseases / diagnosis,  pathology,  physiopathology
Immunosuppressive Agents / adverse effects,  therapeutic use
Myocardium / immunology,  pathology
Predictive Value of Tests
Rheumatic Heart Disease / diagnosis*,  pathology,  physiopathology*
Vasculitis / diagnosis*,  pathology,  physiopathology*
Wegener Granulomatosis / diagnosis,  pathology,  physiopathology
Reg. No./Substance:
0/Immunosuppressive Agents

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