| Involvement of gicerin, a cell adhesion molecule, in a dermal autograft chicken model. | |
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MedLine Citation:
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PMID: 20878087 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Gicerin is a cell adhesion molecule in the immunoglobulin superfamily. This molecule has homophilic and heterophilic adhesive activities, binding to the neurite out-growth factor (NOF). We have previously reported that gicerin plays an important role in the development and regeneration as well as in the metastasis of tumors through its adhesive activities, mediating cell-cell and/or cell-extracellular matrix interactions. In this study, we investigated the involvement of gicerin in a dermal autograft chicken model. Gicerin and NOF were transiently present in the regenerating epithelia after the dermal graft transplantation. The treatment with an anti-gicerin polyclonal antibody, by placing drops onto the wounds, inhibited the adhesiveness of the grafts to the marginal skin. The chimeric protein of gicerin-IgG, gicerin-Fc, and NOF proteins promoted the regeneration of the grafts. These findings suggest the potential function of gicerin in dermal autografts, and gicerin and NOF proteins could help clinical improvement after transplantations. |
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Authors:
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Yasuhiro Tsukamoto; Bin Kataoka; Kazuhide Adachi; Hidenori Kato; Marie Inai; Masaya Tsukamoto; Ekowati Handharyani; Eiichi Taira |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of molecular medicine Volume: 26 ISSN: 1791-244X ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
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Languages: eng Pagination: 661-6 Citation Subset: IM |
Affiliation:
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Department of Animal Hygiene, Graduate School of Biology and Environmental Sciences, Kyoto Prefecture University, Kyoto 606-8522, Japan. ytsuka@kpu.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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