Document Detail


Involvement of gamma-glutamyltransferase in amino-acid uptake by the lactating mammary gland of the rat.
MedLine Citation:
PMID:  6118135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Arteriovenous differences of amino acids across the lactating mammary gland have been measured in normal rats and in rats injected with serine--borate (an inhibitor of gamma-glutamyltransferase). 2. Comparison of the arteriovenous differences show that gamma-glutamyltransferase is involved in amino-acid uptake by the gland. 3. Reduced-glutathione content of isolated acini incubated with high concentrations of amino acids was lower than that of the controls. 4. High concentrations of amino acids had no effect on reduced-glutathione content of isolated acini when serine--borate was added to the incubation medium. 5. The findings provide evidence for the functioning of the gamma-glutamyl cycle in the lactating mammary gland in vivo.
Authors:
J Viña; I R Puertes; J M Estrela; J R Viña; J L Galbis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  194     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-102     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / blood,  metabolism*
Animals
Borates / pharmacology
Female
Glutathione / metabolism
Lactation*
Mammary Glands, Animal / enzymology*
Pregnancy
Rats
Serine / pharmacology
gamma-Glutamyltransferase / antagonists & inhibitors,  metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Borates; 56-45-1/Serine; 70-18-8/Glutathione; EC 2.3.2.2/gamma-Glutamyltransferase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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