| Involvement of gamma-glutamyltransferase in amino-acid uptake by the lactating mammary gland of the rat. | |
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MedLine Citation:
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PMID: 6118135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Arteriovenous differences of amino acids across the lactating mammary gland have been measured in normal rats and in rats injected with serine--borate (an inhibitor of gamma-glutamyltransferase). 2. Comparison of the arteriovenous differences show that gamma-glutamyltransferase is involved in amino-acid uptake by the gland. 3. Reduced-glutathione content of isolated acini incubated with high concentrations of amino acids was lower than that of the controls. 4. High concentrations of amino acids had no effect on reduced-glutathione content of isolated acini when serine--borate was added to the incubation medium. 5. The findings provide evidence for the functioning of the gamma-glutamyl cycle in the lactating mammary gland in vivo. |
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Authors:
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J Viña; I R Puertes; J M Estrela; J R Viña; J L Galbis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 194 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1981 Jan |
Date Detail:
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Created Date: 1982-01-09 Completed Date: 1982-01-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 99-102 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood,
metabolism* Animals Borates / pharmacology Female Glutathione / metabolism Lactation* Mammary Glands, Animal / enzymology* Pregnancy Rats Serine / pharmacology gamma-Glutamyltransferase / antagonists & inhibitors, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Borates; 56-45-1/Serine; 70-18-8/Glutathione; EC 2.3.2.2/gamma-Glutamyltransferase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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