Document Detail

Involvement of dysplasminogenemia in occurrence of deep vein thrombosis.
MedLine Citation:
PMID:  7658107     Owner:  NLM     Status:  MEDLINE    
Although various hematological disorders have been considered to be etiologic factors in deep vein thrombosis (DVT), the involvement of dysplasminogenemia (DPG) in DVT has not been studied in detail. In 72 consecutive DVT patients, the presence of DVT was suspected based on a history of lower limb swelling and tenderness with acute onset, and was confirmed by duplex scanning, radioisotope venography, or contrast venography. DPG was identified by the observation of dissociation between the activity and antigenicity of plasminogen. Of the 72 patients, 9 (12.5%) were diagnosed as having DPG, and several antithrombin-III deficiency and protein C and S deficiency were identified. The mean age of the genetically normal and DPG patients was 52 +/- 15 and 40 +/- 15 years, respectively (p < 0.05). Thus, these findings suggest that DPG is deeply related to the development of DVT, and that abnormality of the fibrinolytic system is one of the major etiologic factors in DVT.
T Kawasaki; J Kambayashi; Y Uemura; M Sakon; E Shiba; E Suehisa; N Amino; T Mori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  14     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-10-05     Completed Date:  1995-10-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
Department of Surgery II, Osaka University Medical School, Japan.
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MeSH Terms
Age Distribution
Antithrombin III Deficiency
Middle Aged
Plasminogen / deficiency,  genetics,  metabolism*
Protein C Deficiency
Protein S Deficiency / complications
Thrombophlebitis / blood,  diagnosis,  etiology*
Reg. No./Substance:

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