Document Detail


Involvement of dopamine and opioids in the motivation to eat: influence of palatability, homeostatic state, and behavioral paradigms.
MedLine Citation:
PMID:  19015837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Motivation for food depends on several variables including food palatability, the homeostatic state of the organism, and the nature of the behavior required to obtain the reward. However, few studies to date have tried to evaluate motivation for food considering all these variables at the same time. Since dopamine and opioids have been deeply involved in the regulation of feeding, it is of interest to investigate their role considering all the mentioned variables. OBJECTIVES: In this study, we evaluated the involvement of dopamine and endogenous opioids on food consumption and food motivation using behavioral paradigms that differ in the motor requirement to gain access to the reward, when food palatability and homeostatic state were taken into account. MATERIALS AND METHODS: Pellets differentiated on palatability were offered to sated and restricted rats in consummatory tests and in different behavioral paradigms measuring motivational state, but requiring different motor outputs (runway and an operant progressive ratio 3 task). Peripheral injections of naloxone or flupenthixol were administered when these tasks were learned and stable. RESULTS: Naloxone decreased food intake when pellets were palatable, while flupenthixol was without any effect. When considering motivation, naloxone decreased performances in both the runway and progressive ratio tests while flupenthixol was only effective in the progressive ratio test. CONCLUSIONS: Impairing the opioid neurotransmission diminishes motivation to obtain food, possibly through a decrease in the perceived palatability of the food reward. The dopaminergic system appears to be more involved in the modulation of motivation to obtain food in a cost/benefit-related manner.
Authors:
M Flavia Barbano; Maryvonne Le Saux; Martine Cador
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-18
Journal Detail:
Title:  Psychopharmacology     Volume:  203     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-17     Completed Date:  2009-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  475-87     Citation Subset:  IM    
Affiliation:
Group Neuropsychopharmacologie de l'addiction, Centre National de Recherche Scientifique, Unité Mixte de Recherche 5227, Universités Bordeaux 2 et Bordeaux 1, 146, rue Léo Saignat - BP 31, 33076 Bordeaux Cedex, France. fbarbano@iib.unsam.edu.ar
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MeSH Terms
Descriptor/Qualifier:
Animals
Dopamine / metabolism,  physiology*
Dopamine Antagonists / pharmacology
Eating / physiology*
Feeding Behavior / physiology*
Flupenthixol / pharmacology
Food Preferences / physiology
Homeostasis / physiology*
Male
Motivation*
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Rats
Rats, Wistar
Receptors, Opioid / antagonists & inhibitors,  physiology*
Chemical
Reg. No./Substance:
0/Dopamine Antagonists; 0/Narcotic Antagonists; 0/Receptors, Opioid; 2709-56-0/Flupenthixol; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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