| Involvement of the direct and indirect pathways of allorecognition in tolerance induction. | |
| | |
MedLine Citation:
|
PMID: 11375067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is generally accepted that there are two pathways of allorecognition, direct and indirect, that together contribute to allograft rejection. Although it has been suggested that the direct pathway predominates during early acute rejection and that the indirect pathway provides a continuous supply of alloantigen responsible for chronic rejection, the true relative contribution of each pathway to the overall rejection process is still not entirely known. It is clear, however, that any strategies designed to achieve the ultimate goal in transplantation, the induction of tolerance, will need to take into account both pathways. This review seeks to explore the involvement of the direct and indirect pathways of allorecognition on a mechanistic level as it relates to the induction of tolerance. A brief historical perspective is included for each pathway as well as a comprehensive review of the mechanisms felt to be active during tolerance induction. |
| | |
Authors:
|
K L Womer; M H Sayegh; H Auchincloss |
Related Documents
:
|
19410687 - Th17 cells and regulatory t cells in primary immunodeficiency diseases. 9316767 - Sjögren's syndrome. controversies and progress. 19015857 - Central tolerance: what have we learned from mice? 17091247 - Fcgammarii and multi-system autoimmune disease. 20420897 - Growth inhibitory and apoptosis inducing by effects of total flavonoids from lysimachia... 3889227 - Biological effects of white-type polysaccharides of gram-negative bacteria. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Philosophical transactions of the Royal Society of London. Series B, Biological sciences Volume: 356 ISSN: 0962-8436 ISO Abbreviation: Philos. Trans. R. Soc. Lond., B, Biol. Sci. Publication Date: 2001 May |
Date Detail:
|
Created Date: 2001-05-25 Completed Date: 2001-09-13 Revised Date: 2008-11-20 |
Medline Journal Info:
|
Nlm Unique ID: 7503623 Medline TA: Philos Trans R Soc Lond B Biol Sci Country: England |
Other Details:
|
Languages: eng Pagination: 639-47 Citation Subset: IM |
Affiliation:
|
Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women'sHospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Humans Isoantigens / immunology* Transplantation Tolerance / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Isoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: T-cell anergy and peripheral T-cell tolerance.
Next Document: Mechanisms of tolerance induction: blockade of co-stimulation.