| Involvement of different mechanisms in the stimulatory effects of cholecystokinin octapeptide on gastrointestinal and colonic motility in dogs. | |
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MedLine Citation:
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PMID: 2611718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of an intravenous infusion of cholecystokinin octapeptide (CCK-8, 1 microgram.kg-1.h-1) were investigated in conscious fasted dogs chronically fitted with strain-gauge transducers on the antrum, the jejunum, and the colon. Attempts to antagonize the increase of motility appearing at the three levels during CCK infusion were made using different blockers to elucidate the mechanisms involved. Asperlicin (a specific CCK antagonist) blocked the effects of CCK-8 at the three levels, while atropine and somatostatin were only effective in the jejunum and colon. Methyl-levallorphan (a mu-opiate antagonist that poorly crosses the blood-brain barrier) antagonized the CCK-induced colonic stimulation when intracerebroventricularly administered. Serotonin, histamine, substance P, and K-antagonists as well as a benzodiazepine did not modify the CCK-8 induced stimulation. It was concluded that the stimulatory effect of CCK-8 resulted from (a) a direct stimulation of the smooth muscle cells at gastric level, (b) a cholinergic activation of the jejunum and the colon, and (c) the involvement of a mu-opioid central component in the colonic response only. |
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Authors:
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M J Fargeas; G Bassotti; J Fioramonti; L Bueno |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 67 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1990-03-09 Completed Date: 1990-03-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 1205-12 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Institut national de la recherche agronomique, Toulouse, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzodiazepinones / administration & dosage, pharmacology Colon / drug effects Dogs Female Gastrointestinal Motility / drug effects* Histamine Antagonists / pharmacology Infusions, Intravenous Injections, Intraventricular Male Narcotic Antagonists / pharmacology Parasympatholytics / pharmacology Serotonin Antagonists / pharmacology Sincalide / antagonists & inhibitors, pharmacology* Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Benzodiazepinones; 0/Histamine Antagonists; 0/Narcotic Antagonists; 0/Parasympatholytics; 0/Serotonin Antagonists; 25126-32-3/Sincalide; 93413-04-8/asperlicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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