Document Detail


Involvement of cyclic AMP in the positive inotropic effect of OPC-8212, a new cardiotonic agent, on the canine ventricular muscle.
MedLine Citation:
PMID:  6097725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OPC-8212 is a new positive inotropic drug which scarcely produces an increase in heart rate and vasodilatation. The positive inotropic effect of OPC-8212 was investigated in relation to cyclic AMP metabolism in canine isolated ventricular muscle. The positive inotropic effect of OPC-8212 was accompanied by accumulation of cyclic AMP in the tissue: the cyclic AMP level was elevated before the increase in force of contraction and elevated in a concentration-dependent manner in the presence of a beta-adrenoceptor antagonist, atenolol (10(-6) M). The OPC-8212-induced increases in force of contraction and cyclic AMP level were abolished by carbachol (3 X 10(-6) M). The relationship between the force of contraction and cyclic AMP level in the presence of OPC-8212 was changed by neither carbachol nor isoproterenol. OPC-8212 enhanced the positive inotropic effect of isoproterenol as cyclic AMP phosphodiesterase inhibitors did. OPC-8212 shortened the time to peak tension and had a tendency to shorten the relaxation time of single contractions. These results altogether suggest that change in cyclic AMP metabolism is involved at least in the positive inotropic effect of OPC-8212 on canine ventricular muscle.
Authors:
T Yanagisawa; M Endoh; N Taira
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  36     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-03-07     Completed Date:  1985-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  379-88     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atenolol / pharmacology
Carbachol / pharmacology
Cardiotonic Agents / pharmacology*
Cyclic AMP / metabolism*
Dogs
Female
Heart / drug effects*
Isoproterenol / pharmacology
Male
Myocardial Contraction / drug effects*
Myocardium / metabolism*
Quinolines / pharmacology*
Stimulation, Chemical
Thiophenes / pharmacology
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Quinolines; 0/Thiophenes; 126-33-0/sulfolane; 29122-68-7/Atenolol; 51-83-2/Carbachol; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol; 81840-15-5/vesnarinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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