| Involvement of constitutive nitric oxide synthase in the portal-systemic collaterals of portal hypertensive rats. | |
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MedLine Citation:
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PMID: 15984816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent studies have shown that endothelial nitric oxide (NO) is involved in modulating the vascular response to vasoconstrictors in portal-systemic collaterals of portal hypertensive rats. This study investigated which isoform of NO synthase is involved in the collateral circulation of portal hypertensive rats. METHODS: The relaxation response to acetylcholine (10(-8) M, 10(-7) M and 10(-6) M) in norepinephrine (NE)-preconstricted portal-systemic collaterals was investigated after incubation with vehicle (Krebs solution), a preferential inducible NO synthase inhibitor (aminoguanidine [AG]), or a non-selective NO synthase inhibitor (Nomega-nitro-L-arginine [NNA]), in rats with partial portal vein ligation. Mean arterial pressure was measured before the perfusion experiments. RESULTS: Bodyweight and mean arterial pressure before the perfusion studies were similar in the vehicle, AG and NNA groups. Preincubation with NNA, but not AG, produced a significant increase in baseline perfusion pressure compared with the vehicle group (p < 0.05). The increase in perfusion pressure in response to NE was enhanced in the presence of NNA (p < 0.05), but not AG. In addition, preincubation with NNA, but not AG, significantly suppressed acetylcholine-induced relaxation in the portal-systemic collaterals (p < 0.05). CONCLUSION: These results suggest that constitutive, rather than inducible, NO synthase is involved in the vascular response to vasoconstrictors in the portal-systemic collaterals of portal hypertensive rats. |
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Authors:
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Ching-Chih Chang; Hui-Chun Huang; Sun-Sang Wang; Fa-Yauh Lee; Full-Young Chang; Han-Chieh Lin; Ming-Chieh Hou; Shou-Dong Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the Chinese Medical Association : JCMA Volume: 68 ISSN: 1726-4901 ISO Abbreviation: J Chin Med Assoc Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-29 Completed Date: 2005-07-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101174817 Medline TA: J Chin Med Assoc Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 245-9 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Collateral Circulation / physiology* Hypertension, Portal / physiopathology* Male Nitric Oxide / physiology Nitric Oxide Synthase / physiology* Nitroarginine / pharmacology Portal System / physiopathology* Rats Rats, Sprague-Dawley Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 51-84-3/Acetylcholine; EC 1.14.13.39/Nitric Oxide Synthase |
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