Document Detail

Involvement of centrosomes in nuclear irregularity of thyroid carcinoma cells.
MedLine Citation:
PMID:  19588164     Owner:  NLM     Status:  MEDLINE    
Nuclear irregularities including nuclear pseudoinclusions and nuclear grooves are characteristic of papillary thyroid carcinoma cells and are regarded as important diagnostic clues in histopathology. We observed nuclear features of thyroid carcinoma cell lines (KTC-1 and TPC-1) in various culture conditions and performed immunocytochemical examinations for cytoskeleton molecules to clarify the morphogenesis of thyroid carcinoma nuclei. We found that nuclear irregularities presenting as bean-like nuclei (BLNs) and donut-like nuclei (DLNs) appeared in cells from confluent cultures, but not in cells from sparse cultures. On immunocytofluorescence analyses, clusters of gamma-tubulin, representing a centrosome, frequently localized at the indentation of BLNs or in the hole of DLNs of thyroid carcinoma cells. In conclusion, we suggest that cell-to-cell contact may affect nuclear changes such as BLNs and DLNs in cancer cell lines and that centrosomes may be involved in the morphogenetic process of these nuclear changes.
Dongfeng Niu; Shin-ichi Murata; Tetsuo Kondo; Tadao Nakazawa; Tomonori Kawasaki; Defu Ma; Tetsu Yamane; Nobuki Nakamura; Ryohei Katoh
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Publication Detail:
Type:  Journal Article     Date:  2009-07-09
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  455     ISSN:  1432-2307     ISO Abbreviation:  Virchows Arch.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  149-57     Citation Subset:  IM    
Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan.
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MeSH Terms
Adenocarcinoma, Follicular / metabolism,  pathology*,  ultrastructure
Carcinoma, Papillary / metabolism,  pathology*,  ultrastructure
Cell Communication / physiology
Cell Line, Tumor
Cell Nucleus / metabolism,  pathology*,  ultrastructure
Centrosome / physiology*
Thyroid Neoplasms / metabolism,  pathology*,  ultrastructure
Tubulin / metabolism
Reg. No./Substance:

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