| Involvement of central, but not placental corticotropin releasing hormone (CRH) in heat stress induced immunosuppression during pregnancy. | |
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MedLine Citation:
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PMID: 11259079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify whether corticotropin releasing hormone (CRH) and beta-endorphin (betaEP) system mediate maternal immunosuppression in pregnant rats exposed to heat through central or placental pathway, we examined the effects of intravenous (iv) (100 or 500 microg) or intracerebroventricular (icv) (5 microg) administration of CRH receptor antagonist alpha-helical CRH (9-41) on splenic natural killer cell activity (NKCA) as well as betaEP in blood, pituitary lobes, and placenta in pregnant rats at 15 to 16 days gestation. Two-way ANOVA revealed that heat reduced NKCA and elevated blood and pituitary betaEP but did not change placental betaEP. Iv administered 500 microg and icv administered alpha-helical CRH reversed the reduced NKCA and the elevated pituitary betaEP, while iv administration of 100 microg alpha-helical CRH did not. The increased blood betaEP was reversed by iv 100 and 500 microg alpha-helical CRH and icv administration. Both iv and icv administrations reduced placental betaEP independent of heat exposure. Thus, the response of placental betaEP to iv administration of alpha-helical CRH seemed to be stronger than that of pituitary betaEP. These results indicate that alpha-helical CRH which acts on pituitary betaEP antagonizes heat-induced immunosuppression during pregnancy, suggesting that immunosuppression produced by heat stress during pregnancy is mediated by the central CRH system. The placental CRH-betaEP system seems unlikely to be involved in the immunosuppression. Physiologic roles of placental CRH and opioid system should be clarified by future in vitro experiments using placenta specimen including placental immunocyte. |
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Authors:
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H Nakamura; H Nagase; K Ogino; K Hatta; I Matsuzaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 15 ISSN: 0889-1591 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-22 Completed Date: 2001-05-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
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Languages: eng Pagination: 43-53 Citation Subset: IM |
Affiliation:
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Department of Public Health, Kanazawa University School of Medicine, Takaramachi 13-1, Kanazawa, 920-8640, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corticotropin-Releasing Hormone / immunology*, metabolism, pharmacology Female Heat Stress Disorders / immunology*, metabolism Hormone Antagonists / pharmacology Injections, Intraventricular Killer Cells, Natural / immunology, metabolism Male Neuroimmunomodulation / drug effects, immunology Opioid Peptides / metabolism Pituitary Gland / immunology*, metabolism Placenta / immunology*, metabolism Pregnancy Pregnancy, Animal / immunology*, metabolism Rats Rats, Wistar beta-Endorphin / blood, immunology |
| Chemical | |
Reg. No./Substance:
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0/Hormone Antagonists; 0/Opioid Peptides; 0/alpha helical corticotropin-releasing hormone; 60617-12-1/beta-Endorphin; 9015-71-8/Corticotropin-Releasing Hormone |
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