| Involvement of carotid baroreceptor function in blood pressure control in the chronic phase: effect on 24-hour ambulatory blood pressure. | |
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MedLine Citation:
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PMID: 18214735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is generally thought that the sole function of baroreceptors is for the regulation of rapid blood pressure fluctuations caused by postural changes and other motion. However, recent studies have suggested that baroreceptors may also be involved in blood pressure control in the chronic phase. PURPOSE: The study was performed to examine the involvement of carotid baroreceptors in blood pressure control in the chronic phase, through determination of the relationship between 24-hour blood pressure data and carotid baroreceptor function. METHODS: Ambulatory blood pressure, ECG, and the number of steps during exercise were measured every 15 minutes with an ambulatory blood pressure monitor and a 24-hour Holter ECG fitted with an accelerometer (Cardy-II-p, Suzuken KK, Japan). In addition, the dependence of blood pressure on autonomic nerve activity and exercise was analyzed based on the frequency of the RR interval. Patients were divided into three groups based on different blood-pressure types: autonomic nerve-dependent, exercise-dependent, and independent types. Carotid baroreceptor function was evaluated using the sequence method; subjects adopted a supine position on a tilt table and their arterial pressure was monitored continuously using a Finapress finger cuff (Finapress, Ohmeda, Louisville, Colorado, USA). The study was performed in 90 patients, including 42 with essential hypertension whose blood pressure was well controlled. RESULTS AND CONCLUSIONS: A significant negative correlation was found between the mean 24-hour blood pressure and baroreceptor function for both systolic and diastolic pressure. Systolic pressure in patients of the independent type was significantly higher than that in patients of the exercise-dependent type. Furthermore, non-dipper hypertension was noted more frequently and baroreceptor function was significantly lower in independent-type patients, compared with autonomic nerve-dependent and exercise-dependent types, suggesting that independent-type blood pressure may be due to baroreceptor dysfunction. In conclusion, our results suggest that baroreceptor function might be involved in blood pressure control in the chronic phase, and baroreceptor dysfunction may contribute to the development of essential hypertension. |
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Authors:
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Eiji Ino-Oka; Hiroshi Sekino; Shinya Kajikawa; Hikaru Inooka; Yutaka Imai; Junichiro Hashimoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 30 ISSN: 1525-6006 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-24 Completed Date: 2008-02-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 69-78 Citation Subset: IM |
Affiliation:
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Kohjinkai Central Hospital, Miyaginoku, Sendai, Japan. ino-oka44442@mni.ne.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autonomic Nervous System / physiology Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Carotid Sinus / physiology* Circadian Rhythm / physiology Electrocardiography, Ambulatory Exercise / physiology Female Humans Hypertension / classification, physiopathology* Male Middle Aged Pressoreceptors / physiology* Tilt-Table Test |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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