Document Detail

Involvement of calcitonin gene-related peptide in the depressor effects of losartan and perindopril in rats.
MedLine Citation:
PMID:  12600696     Owner:  NLM     Status:  MEDLINE    
Previous investigations have indicated that calcitonin gene-related peptide (CGRP) plays an important role in the regulation of cardiovascular function, and that the development of hypertension may be related to the reduction of sensory vasodilator nerve actions. In the present study, we examined the effect of perindopril, an angiotensin-converting enzyme inhibitor, and losartan, an angiotensin II receptor antagonist, on the plasma level and synthesis of CGRP in 2 kidneys, 1-clip hypertensive rats (2K1C, Goldblatt). In the hypertension group, systolic blood pressure and mean artery pressure were raised, and the level of CGRP in plasma was slightly raised compared with control groups. Chronic treatment with losartan or perindopril significantly increased the plasma concentration of CGRP and the expression of CGRP mRNA in dorsal root ganglia in the 2K1C, Goldblatt hypertensive rats. These results suggest that the 2K1C, Goldblatt hypertensive model has a compensatory increase of sensory nerve actions, and that the depressor effects of perindopril or losartan may be related to stimulation of the synthesis and release of CGRP in the 2K1C, Goldblatt hypertensive rats.
Xu-Ping Qin; Feng Ye; Duan-Fang Liao; Yuan-Jian Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  464     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-25     Completed Date:  2003-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  63-7     Citation Subset:  IM    
Department of Pharmacology, Xiang-Ya School of Medicine, Central South University, Hunan 410078., Changsha, PR China.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Calcitonin Gene-Related Peptide / blood*,  genetics
Gene Expression
Hypertension, Renovascular / genetics,  physiopathology
Losartan / pharmacology*
Perindopril / pharmacology*
RNA, Messenger / genetics,  metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/RNA, Messenger; 114798-26-4/Losartan; 82834-16-0/Perindopril; 83652-28-2/Calcitonin Gene-Related Peptide

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