| Involvement of c-Ski Oncoprotein in Carcinogenesis of Cholangiocacinoma Induced by Opisthorchis viverrini and N-nitrosodimethylamine. | |
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MedLine Citation:
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PMID: 20853076 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Opisthorchiasis is the major public health problem in the endemic areas of Thailand and Laos because Opisthorchis viverrini infection causes serious hepatobiliary diseases including CCA. The molecular mechanism of the CCA carcinogenesis induced by the infection remains obscure. To reveal the potential genes and signaling pathways to involve in the carcinogenesis, the present study investigated the expression of c-Ski, an oncogene, and two TGF-β signaling pathway relative genes, TGF-β and Smad4, during the development of CCA induced by O. viverrini infection in hamster model, and in human opisthorchiasis associated CCA. The results showed that the expression of c-Ski gene was greatly up-regulated during the carcinogenesis of CCA in hamster model. The overexpression of c-Ski was confirmed by immunohistological staining result which showed the increased expression of c-Ski protein in cytoplasm of the epithelial lining of hepatic bile ducts. Moreover, the immunohistological staining of the specimens of human opisthorchiasis associated CCA revealed the up-regulated expression of c-Ski and Smad4 proteins in the cytoplasm of the epithelial lining of hepatic bile ducts and stomal fibrosis respectively. The expression of TGF-β and Smad4 were up-regulated, which expression kinetics was time-dependent of CCA development. These results suggest that c-Ski is likely involved in the carcinogenesis of CCA induced by O. viverrini infection through regulating TGF-β signaling pathway. |
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Authors:
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Thidarut Boonmars; Zhiliang Wu; Sirintip Boonjaruspinyo; Anucha Puapairoj; Butsara Kaewsamut; Isao Nagano; Somchai Pinlaor; Puangrat Yongvanit; Orasa Wonkchalee; Amornrat Juasook; Pakkayanee Sudsarn; Tuanchai Srisawangwong |
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Publication Detail:
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Type: Journal Article Date: 2010-09-18 |
Journal Detail:
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Title: Pathology oncology research : POR Volume: 17 ISSN: 1532-2807 ISO Abbreviation: Pathol. Oncol. Res. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706087 Medline TA: Pathol Oncol Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 219-27 Citation Subset: IM |
Affiliation:
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Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand, bthida@kku.ac.th. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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