Document Detail


Involvement of P2Y Receptors in Myocardial Contractile Activity of Rats during Postnatal Ontogeny.
MedLine Citation:
PMID:  22803161     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We studied the effect of uridine 5'-triphosphate in concentrations of 10(-10)-10(-6)M on myocardial contractile activity in 7-100-day-old rats. Analysis of isometric contraction of myocardial strips showed that uridine 5'-triphosphate reduced the strength of myocardial contraction in rats of all age groups. In 21- and 100-day-old rat pups, exogenous uridine 5'-triphosphate produced a stronger inhibitory effect than in 7-day-old animals. The negative inotropic effect of UTP was abolished under conditions of P2Y(4)purinoceptor blockade with reagent blue-2. These data indicate that the effect of UTP on the myocardium is realized via P2Y(4)purinoceptors.
Authors:
T A Anikina; I N Anisimova; F G Sitdikov
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  152     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-07-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  672-4     Citation Subset:  IM    
Affiliation:
Department of Human Anatomy and Physiology, Tatar State HumanitarianandTraining University, Kazan, Russia. tania57vg1@rambler.ru, irina171185@rambler.ru.
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