| Involvement of orexigenic peptides in the mechanism of gastric mucosal integrity and healing of chronic gastric ulcers. | |
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MedLine Citation:
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PMID: 20166991 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Orexigenic peptides are group of endocrine hormones exerting a pleiotropic influence on many physiological functions including regulation of the feeding behaviour and energy expenditure, release of growth hormone (GH) and inotropic effects on the heart. Some of these peptides such as ghrelin, originally identified in the gastric mucosa, has been involved not only in control of food intake and growth hormone release but also exerts the immunomodulatory and anti-inflammatory properties. This review summarizes the recent attempts to prove the concept that orexigenic peptides such as ghrelin, orexin-A and obestatin besides playing an important role in the mechanism of food intake, exhibit a potent gastroprotective action against the formation of acute gastric mucosal injury induced by various ulcerogens. This protective effect depends upon vagal activity and hyperemia mediated by NOS/NO and COX/PG systems and CGRP released from sensory afferent nerves. In addition, the appetite peptides such as ghrelin and orexin-A are implicated in the mechanism of the healing of preexisting gastric ulcers due to an activation of specific GHS-R1a and OX-R1 receptors and PG/COX system. |
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Authors:
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Aleksandra Szlachcic; Thomas Brzozowski; Jolanta Majka; Robert Pajdo; Peter C Konturek; Michal Pawlik; Slawomir Kwiecien; Danuta Drozdowicz; Wladyslaw Bielanski; Stanislaw J Konturek; Wieslaw W Pawlik |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current pharmaceutical design Volume: 16 ISSN: 1873-4286 ISO Abbreviation: Curr. Pharm. Des. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1214-23 Citation Subset: IM |
Affiliation:
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Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka, Street, 31-531 Cracow, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Stimulants / pharmacology* Cyclooxygenase 2 Inhibitors / pharmacology Gastric Mucosa / blood supply, drug effects*, innervation Ghrelin / administration & dosage, pharmacology*, physiology Helicobacter Infections / pathology Helicobacter pylori Humans Intracellular Signaling Peptides and Proteins / administration & dosage, pharmacology*, physiology Neuropeptides / administration & dosage, pharmacology*, physiology Neurotransmitter Agents / pharmacology Rats Stomach Ulcer / drug therapy*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Appetite Stimulants; 0/Cyclooxygenase 2 Inhibitors; 0/Ghrelin; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/Neurotransmitter Agents; 0/orexins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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