Document Detail


Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition.
MedLine Citation:
PMID:  23152124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-loaded P-MSNs by improving cell killing.
Authors:
Rolando E Yanes; Derrick Tarn; Angela A Hwang; Daniel P Ferris; Sean P Sherman; Courtney R Thomas; Jie Lu; April D Pyle; Jeffrey I Zink; Fuyuhiko Tamanoi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-14
Journal Detail:
Title:  Small (Weinheim an der Bergstrasse, Germany)     Volume:  9     ISSN:  1613-6829     ISO Abbreviation:  Small     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-04     Revised Date:  2014-08-20    
Medline Journal Info:
Nlm Unique ID:  101235338     Medline TA:  Small     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  697-704     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Drug Carriers / chemistry*
Exocytosis / physiology
Humans
Lysosomes / chemistry*
Nanoparticles / chemistry*
Silicon Dioxide / chemistry*
Grant Support
ID/Acronym/Agency:
P30 CA016042/CA/NCI NIH HHS; R01 CA133697/CA/NCI NIH HHS; R01 CA133697/CA/NCI NIH HHS; T32 GM067555/GM/NIGMS NIH HHS; T32GM067555/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Drug Carriers; 7631-86-9/Silicon Dioxide
Comments/Corrections

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