| Involvement of HLDF Protein and Anti-HLDF Antibodies in the Mechanisms of Blood Pressure Regulation in Healthy Individuals and Patients with Stable Hypertension and Hypertensive Crisis. | |
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MedLine Citation:
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PMID: 23113252 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We studied the relationships between the blood serum levels of human leukemia differentiation factor HLDF, idiotypic and anti-idiotypic antibodies to HLDF, and clinical indicators of cardiovascular function in apparently healthy individuals and patients with essential hypertension and cerebral hypertensive crisis. Markedly reduced HLDF levels and anti-HLDF antibody titers were found in the blood of the examined patients. Correlations between HLDF levels, duration of hypertension, and systolic and diastolic BP were revealed. These findings suggest that the studied molecular factors are involved in the mechanisms of BP regulation under normal conditions and during hypertension development. The protein HLDF and anti-HLDF antibodies can be considered as biomarkers for early diagnosis of hypertension and its cerebral complications. |
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Authors:
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E I Elistratova; M A Gruden; V V Sherstnev |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 153 ISSN: 1573-8221 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng; rus Pagination: 664-6 Citation Subset: IM |
Affiliation:
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P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. mgruden@mail.ru. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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