Document Detail


Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects of Scrophularia striata extract in rats.
MedLine Citation:
PMID:  23373710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Neuropsychiatric disorders, like anxiety and depression, are global problems for clinical researchers in neurology. Recently, some authors have shown neuroprotective and anti-inflammatory effects of Scrophularia striata Boiss (Scrophulariaceae) extract in rodents.
OBJECTIVE: The purpose of the current study was to investigate the effects of S. striata extract on anxiety and depressant-like behaviors and find a possible mechanism for these impacts.
MATERIALS AND METHODS: In this study, the elevated plus-maze (EPM) and forced swimming test (FST), which are useful models for selective identification of anxiolytic and antidepressant drug effects in rodents, were used. We investigated the effects of S. striata ethanol extract at different doses (20, 50, 100, 160 and 220 mg/kg) on anxiety and depression behaviors in the EPM and FST, and then we assessed the role of γ-aminobutyric acid (GABA)A receptor in modulation of the effects of S. striata extract in the brain.
RESULTS: Our results showed that effective doses of S. striata (100 and 160 mg/kg) increased the percentages of open arm time and entries in the EPM and decreased immobility time in the FST in comparison with control group, indicating anxiolytic and antidepressant effects, respectively. Moreover, intracerebroventricular administration of GABAA receptor agonist (muscimol; 1 µg/rat) enhanced the impact of S. striata, and GABAA receptor antagonist (bicuculline; 1 µg/rat) blocked these effects in rats, indicating that significant interactions existed between S. striata and the GABAergic system in the brain.
DISCUSSION AND CONCLUSION: Findings of this study suggest that anxiolytic and antidepressant effects of S. striata may be modulated via the GABAergic system.
Authors:
Morteza Kosari-Nasab; Shirin Babri; Laleh Fatehi-Gharehlar; Mohammad-Hossein Doosti; Sara Pakzad
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-04
Journal Detail:
Title:  Pharmaceutical biology     Volume:  51     ISSN:  1744-5116     ISO Abbreviation:  Pharm Biol     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-19     Completed Date:  2013-10-31     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9812552     Medline TA:  Pharm Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  581-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Anxiety Agents / administration & dosage,  isolation & purification,  pharmacology*
Antidepressive Agents / administration & dosage,  isolation & purification,  pharmacology*
Anxiety / drug therapy,  physiopathology
Bicuculline / pharmacology
Brain / drug effects,  metabolism
Depression / drug therapy,  physiopathology
Disease Models, Animal
Dose-Response Relationship, Drug
Injections, Intraventricular
Male
Maze Learning / drug effects
Muscimol / pharmacology
Plant Extracts / administration & dosage,  pharmacology*
Rats
Rats, Wistar
Receptors, GABA-A / drug effects,  metabolism
Scrophularia / chemistry*
Swimming / psychology
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/Plant Extracts; 0/Receptors, GABA-A; 2763-96-4/Muscimol; Y37615DVKC/Bicuculline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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