Document Detail

Involvement of the femoropopliteal arteries in giant cell arteritis: clinical and color duplex sonography.
MedLine Citation:
PMID:  22247342     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the extent and clinical significance of giant cell arteritis (GCA) of the femoropopliteal arteries.
METHODS: This was a retrospective clinical color duplex sonography (CDS) study; 60 of 112 consecutive patients with the diagnosis of GCA underwent complete clinical examination of the lower extremities including the vasculature, systolic ankle pressure measurement, and CDS scans of the femoropopliteal arteries within 1 year after diagnosis of GCA. Circumferential, hypoechogenic, homogenous wall thickening was regarded as a hallmark of femoropopliteal GCA.
RESULTS: GCA of femoropopliteal arteries was present in 32 (53.3%) of 60 patients. In general, femoropopliteal GCA developed bilaterally (100%) and 14 patients (23.3%) had significant lower extremity artery obstructions secondary to vasculitis, all leading to symptomatic lower extremity ischemia, with development of critical leg ischemia in 4 patients. Compared with subjects without lower extremity vasculitis, patients with femoropopliteal involvement had a significant time delay until diagnosis (mean 23.9 vs 11.1 weeks; p = 0.03) and a higher frequency of concomitant vasculitis of the arm arteries (74.2% vs 42.9%; p = 0.02).
CONCLUSION: Femoropopliteal artery involvement appears to be a clinically relevant manifestation of GCA, frequently leading to symptomatic lower extremity ischemia. CDS of the femoropopliteal arteries is a noninvasive diagnostic tool for detection of lower extremity vasculitis in GCA.
Michael Czihal; Federico Tatò; Antje Rademacher; Peter Kuhlencordt; Hendrik Schulze-Koops; Ulrich Hoffmann
Publication Detail:
Type:  Journal Article     Date:  2012-01-15
Journal Detail:
Title:  The Journal of rheumatology     Volume:  39     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-02     Completed Date:  2012-06-05     Revised Date:  2012-10-25    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  314-21     Citation Subset:  IM    
Division of Vascular Medicine, Medical Policlinic, University Hospital, Campus City Center, Munich, Germany.
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MeSH Terms
Constriction, Pathologic / ultrasonography
Femoral Artery / ultrasonography
Giant Cell Arteritis / ultrasonography*
Lower Extremity / blood supply,  ultrasonography
Middle Aged
Popliteal Artery / ultrasonography*
Retrospective Studies
Ultrasonography, Doppler, Color*
Comment In:
J Rheumatol. 2012 Sep;39(9):1898-9; author reply 1899   [PMID:  22942306 ]

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