Document Detail

Involvement of F-actin in chaperonin-containing t-complex 1 beta regulating mouse mesangial cell functions in a glucose-induction cell model.
MedLine Citation:
PMID:  22144988     Owner:  NLM     Status:  MEDLINE    
The aim of this study is to investigate the role of chaperonin-containing t-complex polypeptide 1 beta (CCT2) in the regulation of mouse mesangial cell (mMC) contraction, proliferation, and migration with filamentous/globular-(F/G-) actin ratio under high glucose induction. A low CCT2 mMC model induced by treatment of small interference RNA was established. Groups with and without low CCT2 induction examined in normal and high (H) glucose conditions revealed the following major results: (1) low CCT2 or H glucose showed the ability to attenuate F/G-actin ratio; (2) groups with low F/G-actin ratio all showed less cell contraction; (3) suppression of CCT2 may reduce the proliferation and migration which were originally induced by H glucose. In conclusion, CCT2 can be used as a specific regulator for mMC contraction, proliferation, and migration affected by glucose, which mechanism may involve the alteration of F-actin, particularly for cell contraction.
Jin-Shuen Chen; Li-Chien Chang; Chia-Chao Wu; Lai-King Yeung; Yuh-Feng Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-15
Journal Detail:
Title:  Experimental diabetes research     Volume:  2011     ISSN:  1687-5303     ISO Abbreviation:  Exp Diabetes Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-06     Completed Date:  2012-04-05     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101274844     Medline TA:  Exp Diabetes Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  565647     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Jin-Shuen Chen et al.
Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan.
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MeSH Terms
Actins / metabolism*
Cell Movement / drug effects,  physiology
Cell Proliferation / drug effects
Cells, Cultured
Chaperonin Containing TCP-1 / antagonists & inhibitors,  genetics,  metabolism*
Glucose / metabolism,  pharmacology
Mesangial Cells / cytology,  drug effects,  physiology*
Models, Biological
RNA, Small Interfering / genetics
Reg. No./Substance:
0/Actins; 0/RNA, Small Interfering; 0/Tcp1 protein, mouse; 50-99-7/Glucose; EC 3.6.1.-/Chaperonin Containing TCP-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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